ArticleOncogene2017
Mitochondrial stress-induced p53 attenuates HIF-1α activity by physical association and enhanced ubiquitination.
Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Tumor metabolome remolded by low dose mitochondrial uncoupler elicites robust CD8Cell death discovery · 2025Article
- Metabolic Roles of HIF1, c-Myc, and p53 in Glioma Cells.Metabolites · 2024Review
- Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors.Acta pharmaceutica Sinica. B · 2022Article
- The potential role and trend of HIF‑1α in intervertebral disc degeneration: Friend or foe? (Review).Molecular medicine reports · 2021Review
- The role of ubiquitination and deubiquitination in cancer metabolism.Molecular cancer · 2020Review
- Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling.iScience · 2020Article
- PTP4A3, A Novel Target Gene of HIF-1alpha, Participates in Benzene-Induced Cell Proliferation Inhibition and Apoptosis through PI3K/AKT Pathway.International journal of environmental research and public health · 2020Article
- HIF-transcribed p53 chaperones HIF-1α.Nucleic acids research · 2019Article
- Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment.Cells · 2019Review
- Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.Cancer science · 2018Article
- Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1α-induced pro-angiogenic factor.Cancer science · 2018Article
- The hypoxia-responsive lncRNAOncotarget · 2018Article
- Epigenetic modification of miR-663 controls mitochondria-to-nucleus retrograde signaling and tumor progression.The Journal of biological chemistry · 2017Article
- Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.Seminars in cancer biology · 2017Review
- Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection.Biochimica et biophysica acta. Bioenergetics · 2017Review
- mtDNA as a Mediator for Expression of Hypoxia-Inducible Factor 1α and ROS in Hypoxic Neuroblastoma Cells.International journal of molecular sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Retrograde signaling is a mechanism by which mitochondrial dysfunction is communicated to the nucleus for inducing a metabolic shift essential for cell survival. Previously, we showed that partial mitochondrial DNA (mtDNA) depletion in different cell types induced mitochondrial retrograde signaling pathway (MtRS) involving Ca
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.