ArticleScientific reports2016
Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Histological and Immunohistochemical Methods in Normal and Osteoarthritic Knee Cartilage of Rat and Rabbit Models: A Literature Review.International journal of molecular sciences · 2025Pooled it
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- The calcitonin receptor controls osteophyte formation, but not cartilage degeneration and subchondral bone loss in experimental osteoarthritis.Bone & joint research · 2026Article
- Roles of metabolic dysregulation in osteoarthritis.Frontiers in cell and developmental biology · 2026Review
- Verification of Pain-Related Neuromodulation Mechanisms of Calcitonin in Knee Osteoarthritis.Molecular neurobiology · 2025Article
- Calcitonin treatment for osteoarthritis and rheumatoid arthritis - a systematic review and meta-analysis of preclinical data.EFORT open reviews · 2024Article
- Intra-Articular Lactate Dehydrogenase A Inhibitor Oxamate Reduces Experimental Osteoarthritis and Nociception in Rats via Possible Alteration of Glycolysis-Related Protein Expression in Cartilage Tissue.International journal of molecular sciences · 2023Article
- Bone marrow lesions in osteoarthritis: From basic science to clinical implications.Bone reports · 2023Article
- Inactivation of the gene encoding procalcitonin prevents antibody-mediated arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- Efficacy of Intramuscular Injection of Calcitonin on Pain Functional Status of Patients with Knee Osteoarthritis.Anesthesiology and pain medicine · 2023Article
- Protective effects of equol on the cartilage and subchondral bone in ovariectomized rats with osteoarthritis.Iranian journal of basic medical sciences · 2022Article
- Assessment of osteoarthritis functional outcomes and intra-articular injection volume in the rat anterior cruciate ligament transection model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Ketogenic diet ameliorates inflammation by inhibiting the NLRP3 inflammasome in osteoarthritis.Arthritis research & therapy · 2022Article
- Article
- The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis.iScience · 2022Article
- PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis.Bone & joint research · 2021Article
- Raloxifene inhibits the overexpression of TGF-β1 in cartilage and regulates the metabolism of subchondral bone in rats with osteoporotic osteoarthritis.Bosnian journal of basic medical sciences · 2021Article
- Effects ofExperimental and therapeutic medicine · 2021Article
- Etoricoxib prevents progression of osteolysis in repeated intra-articular monosodium urate-induced gouty arthritis in rats.Journal of advanced research · 2020Article
- Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the role of the calcitonin (Miacalcin) in the progression of osteoarthritis (OA) and in nociceptive behavior in an experimental rat model of OA and osteoporosis. OA was induced by anterior cruciate ligament transection (ACLT) of the right knee and by bilateral ovariectomy (OVX) in Wistar rats. Nociceptive behaviors (secondary mechanical allodynia and weight-bearing distribution of the hind paws) were analyzed prior to surgery and every week, beginning at 12 weeks after surgery, up to 20 weeks. At 20 weeks, histopathological studies were performed on the cartilage of the knee joints. Immunohistochemical analysis was performed to examine the effect of calcitonin on transforming growth factor (TGF)-β1 expression in articular cartilage chondrocytes. Rats subjected to ACLT + OVX surgery showed obvious OA changes in the joints. Animals subjected to ACLT + OVX and treated with calcitonin showed significantly less cartilage degeneration and improved nociceptive tests compared with animals subjected to ACLT + OVX surgeries alone. Moreover, calcitonin increased TGF-β1 expression in chondrocytes in ACLT + OVX-affected cartilage. Subcutaneous injection of calcitonin (1) attenuated the development of OA, (2) concomitantly reduced nociception, and (3) modulated chondrocyte metabolism, possibly by increasing cellular TGF-β1 expression.
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