ArticleScientific reports2016
A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- A comprehensive metabolic profiling of the metabolically healthy obesity phenotype.Lipids in health and disease · 2020Trial
- Effect of weight loss on circulating fatty acid profiles in overweight subjects with high visceral fat area: a 12-week randomized controlled trial.Nutrition journal · 2018Trial
- Amino acid-based biological age clock and its implications for human health and aging.Nature communications · 2026Article
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- Macrophages in metaflammation - fueling chronic inflammation in metabolic disease.Pflugers Archiv : European journal of physiology · 2025Review
- Targeting Lipophagy in Liver Diseases: Impact on Oxidative Stress and Steatohepatitis.Antioxidants (Basel, Switzerland) · 2025Review
- Effect of obesity and exercise training on circulating lipids in American Indian adolescents.PloS one · 2025Article
- Article
- Associations of fatty acids composition and estimated desaturase activities in erythrocyte phospholipids with biochemical and clinical indicators of cardiometabolic risk in non-diabetic Serbian women: the role of level of adiposity.Frontiers in nutrition · 2023Article
- The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.International journal of molecular sciences · 2022Article
- A bioactive component ofToxicology research · 2022Article
- Estimated Elovl6 and delta-5 desaturase activities might represent potential markers for insulin resistance in Japanese adults.Journal of diabetes and metabolic disorders · 2022Article
- Relationship between estimated desaturase enzyme activity and metabolic syndrome in a longitudinal study.Frontiers in nutrition · 2022Article
- Combination of TRP channel dietary agonists induces energy expending and glucose utilizing phenotype in HFD-fed mice.International journal of obesity (2005) · 2022Article
- Dual Roles of Coconut Oil and Its Major Component Lauric Acid on Redox Nexus: Focus on Cytoprotection and Cancer Cell Death.Frontiers in neuroscience · 2022Article
- Existing knowledge on Zn status biomarkers (1963-2021) with a particular focus on FADS1 and FADS2 diagnostic performance and recommendations for further research.Frontiers in nutrition · 2022Review
- The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives.Cells · 2021Review
- Oleic acid to stearic acid ratio might be a potential marker for insulin resistance in non-obese Japanese.Journal of clinical biochemistry and nutrition · 2021Article
- Lipid droplet biogenesis and COX-2 pathway activation are triggered by Barrett's esophagus and adenocarcinoma, but not esophageal squamous cell carcinoma risk factors.Scientific reports · 2021Article
- Short-Term Changes in Metabolically Healthy Overweight/Obesity Status Impact the Susceptibility to Type 2 Diabetes in Chinese Adults.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
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Authors and funding
15 authors at 5 institutions in 2 countries.
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Abstract
Increasing evidences support that metabolically healthy obese (MHO) is a transient state. However, little is known about the early markers associated with the development of metabolic abnormalities in MHO individuals. Serum free fatty acids (FFAs) profile is highlighted in its association with obesity-related insulin resistance, type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). To examine the association of endogenous fatty acid metabolism with future development of metabolic abnormalities in MHO individuals, we retrospectively analyzed 24 [product FFA]/[precursor FFA] ratios in fasting sera and clinical data from 481 individuals who participated in three independent studies, including 131 metabolic healthy subjects who completed the 10-year longitudinal Shanghai Diabetes Study (SHDS), 312 subjects cross-sectionally sampled from the Shanghai Obesity Study (SHOS), and 38 subjects who completed an 8-week very low carbohydrate diet (VLCD) intervention study. Results showed that higher baseline level of oleic acid/stearic acid (OA/SA), and lower levels of stearic acid/palmitic acid (SA/PA) and arachidonic acid/dihomo-γ-linolenic acid (AA/DGLA) ratios were associated with higher rate of MHO to MUO conversion in the longitudinal SHDS. Further, the finding was validated in the cross-sectional and interventional studies. This panel of FFA ratios could be used for identification and early intervention of at-risk obese individuals.
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