ArticleJournal of molecular medicine (Berlin, Germany)2016
CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Journal of molecular medicine (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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33citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies.Journal of neuroinflammation · 2023Pooled it
- Advances in diagnosing and treating diabetic retinopathy.Nature reviews. Endocrinology · 2026Review
- Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cytokines in age-related eye diseases: pathogenesis and potential targets for innovative therapies.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The role of microglia in the development of diabetic retinopathy and its potential clinical application.Human cell · 2025Review
- The Role of Fractalkine in Diabetic Retinopathy: Pathophysiology and Clinical Implications.International journal of molecular sciences · 2025Review
- A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes.Nature metabolism · 2024Article
- The role of microglia in the development of diabetic retinopathy.npj metabolic health and disease · 2024Review
- Macrophage activation contributes to diabetic retinopathy.Journal of molecular medicine (Berlin, Germany) · 2024Review
- NOD1 deficiency ameliorates the progression of diabetic retinopathy by modulating bone marrow-retina crosstalk.Stem cell research & therapy · 2024Article
- Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina.Journal of neuroinflammation · 2024Article
- Association between macrophage-like cell density and ischemia metrics in diabetic eyes.Experimental eye research · 2023Article
- Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration.Journal of neuroinflammation · 2023Article
- Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation.International journal of molecular sciences · 2023Review
- CXInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- Elucidating glial responses to products of diabetes-associated systemic dyshomeostasis.Progress in retinal and eye research · 2023Review
- Macrophage-like Cells Are Increased in Patients with Vision-Threatening Diabetic Retinopathy and Correlate with Macular Edema.Diagnostics (Basel, Switzerland) · 2022Article
- Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease.Journal of neuroinflammation · 2022Article
- Enhancing fractalkine/CX3CR1 signalling pathway can reduce neuroinflammation by attenuating microglia activation in experimental diabetic retinopathy.Journal of cellular and molecular medicine · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 6 institutions in 1 country.
Eleni BeliEugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
James M DominguezEugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Ping HuEugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Jeffrey S ThinschmidtDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.
Sergio CaballeroDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.
Sergio Li CalziEugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Defang LuoDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.
Sumathi ShanmugamDepartment of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA.
Tatiana E SalazarEugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Yaqian DuanEugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Michael E BoultonEugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Susanna MohrDepartment of Physiology, Michigan State University, East Lancing, MI, USA.
Steven F AbcouwerDepartment of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA.
Daniel R SabanDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Jeffrey K HarrisonDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.
Maria B GrantEugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA. mabgrant@iupui.edu.
University of Florida · USIndiana University School of MedicineIndiana University – Purdue University Indianapolis · USUniversity of Michigan–Ann Arbor · USDuke University · USMichigan State University · US
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MVISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3MTranslation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MNITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6MTargeting the IGF-1 System in Retinal AngiogenesisR01EY007739 · NEI · UNIVERSITY OF FLORIDA · PI ABCOUWER, STEVEN F, GRANT, MARIA BARTOLOMEO · 1995 to 2015
$5.4MLXR as a Novel Therapeutic Target in Diabetic RetinopathyR01EY025383 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUSIK, JULIA V, GRANT, MARIA BARTOLOMEO · 2015 to 2024
$4.2MRegulation of Retinal Cell Death in DiabetesR01EY020582 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABCOUWER, STEVEN F, GARDNER, THOMAS W. · 2010 to 2018
$4.0MTargeting gamma-secretase activation for anti-angiogenesisR01EY018358 · NEI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BOULTON, MICHAEL EDWIN · 2007 to 2012
$2.2MVascular Reparative Mechanism by ACE2/Ang-(1-7)in DiabetesR01HL110170 · NHLBI · UNIVERSITY OF FLORIDA · PI GRANT, MARIA BARTOLOMEO · 2011 to 2015
$2.2MIL-1 beta Signaling in Diabetic RetinopathyR01EY017206 · NEI · MICHIGAN STATE UNIVERSITY · PI MOHR, SUSANNE · 2006 to 2010
$1.5MNO Dysregulation of the Peripheral Clock in Diabetic ComplicationsR01DK090730 · NIDDK · UNIVERSITY OF FLORIDA · PI GRANT, MARIA BARTOLOMEO · 2010 to 2013
$1.3MNEI NIH HHS P30 EY005722NEI NIH HHS R01 EY007739NEI NIH HHS R01 EY012601NEI NIH HHS R01 EY017206NEI NIH HHS R01 EY018358NEI NIH HHS R01 EY020582NEI NIH HHS R01 EY025383NHLBI NIH HHS R01 HL110170NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK090730
Abstract
In this study, the role of CX3CR1 in the progression of diabetic retinopathy (DR) was investigated. The retinas of wild-type (WT), CX3CR1 null (CX3CR1 KEY MESSAGES: • CX3CR1 deletion in STZ-diabetic mice accelerated the onset of diabetic retinopathy (DR). • The early onset of DR was associated with increased retinal cell apoptosis. • The early onset of DR was associated with increased recruitment of bone marrow-derived macrophages to the retina. • Bone marrow-derived macrophages from CX3CR1 KO diabetic mice expressed more TNF-α and less IL-10. • The role of IL-10 in protection from progression of DR is highlighted.
Indexed as
AnimalsApoptosisBody WeightBone Marrow CellsCX3C Chemokine Receptor 1Diabetes Mellitus, Type 1Diabetic RetinopathyDisease Models, AnimalGene DeletionGlycated HemoglobinHomeostasisHypothalamusInflammationInflammation MediatorsInterleukin-10MacrophagesCX3C Chemokine Receptor 1Cx3cr1 protein, mouseGlycated HemoglobinInflammation MediatorsInterleukin-10RNA, MessengerStreptozocinApoptosisCX3CR1DiabetesIL-10MacrophagesRetinopathy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.