ArticleJournal of materials science. Materials in medicine2016
A superhydrophilic titanium implant functionalized by ozone gas modulates bone marrow cell and macrophage responses.
Article in Journal of materials science. Materials in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Alkaline Ozonation-Induced TiOJournal of functional biomaterials · 2026Article
- Article
- Effects of joint irrigation combined with ozone injection on bone metabolism, inflammatory factors, and joint function in knee osteoarthritis.American journal of translational research · 2023Article
- Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation.Bioactive materials · 2022Article
- In vitro response of THP-1 derived macrophages to antimicrobially effective PHMB-coated Ti6Al4V alloy implant material with and without contamination with S. epidermidis and P. aeruginosa.Biomaterials research · 2022Article
- Control of innate immune response by biomaterial surface topography, energy, and stiffness.Acta biomaterialia · 2021Review
- Tailoring Materials with Specific Wettability in Biomedical Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application.Biology · 2021Article
- Article
- Extension of hydrophilicity stability by reactive plasma treatment and wet storage on TiOJournal of the Royal Society, Interface · 2020Article
- Ozonized Gel Against FourMaterials (Basel, Switzerland) · 2020Article
- Enhanced Osseointegration Capability of Poly(ether ether ketone) via Combined Phosphate and Calcium Surface-Functionalization.International journal of molecular sciences · 2019Article
- Synergistic effect of surface phosphorylation and micro-roughness on enhanced osseointegration ability of poly(ether ether ketone) in the rabbit tibia.Scientific reports · 2018Article
- Hydrothermal Sterilization Improves Initial Osteoblast Responses on Sandpaper-Polished Titanium.Materials (Basel, Switzerland) · 2017Article
- Effect of Different Titanium Surfaces on Maturation of Murine Bone Marrow-Derived Dendritic Cells.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone-forming cells and Mϕ play key roles in bone tissue repair. In this study, we prepared a superhydrophilic titanium implant functionalized by ozone gas to modulate osteoconductivity and inhibit inflammatory response towards titanium implants. After 24 h of ozone gas treatment, the water contact angle of the titanium surface became zero. XPS analysis revealed that hydroxyl groups were greatly increased, but carbon contaminants were largely decreased 24 h after ozone gas functionalization. Also, ozone gas functionalization did not alter titanium surface topography. Superhydrophilic titanium (O3-Ti) largely increased the aspect ratio, size and perimeter of cells when compared with untreated titanium (unTi). In addition, O3-Ti facilitated rat bone marrow derived MSCs differentiation and mineralization evidenced by greater ALP activity and bone-like nodule formation. Interestingly, O3-Ti did not affect RAW264.7 Mϕ proliferation. However, naive RAW264.7 Mϕ cultured on unTi produced a two-fold larger amount of TNFα than that on O3-Ti. Furthermore, O3-Ti greatly mitigated proinflammatory cytokine production, including TNFα and IL-6 from LSP-stimulated RAW264.7 Mϕ. These results demonstrated that a superhydrophilic titanium prepared by simple ozone gas functionalization successfully increased MSCs proliferation and differentiation, and mitigated proinflammatory cytokine production from both naive and LPS-stimulated Mϕ. This superhydrophilic surface would be useful as an endosseous implantable biomaterials and as a biomaterial for implantation into other tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.