Evidence map›Paper›PMID 27344335›Full record

Observational studyClinical and experimental nephrology2017

The use of vitamin D analogs is independently associated with the favorable renal prognosis in chronic kidney disease stages 4-5: the CKD-ROUTE study.

Yohei Arai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Tomoki Kawasaki, Hidehiko Sato, Ryoichi Ando, Sei Sasaki, Eisei Sohara and 3 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical and experimental nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Observational
  6. Observational
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Yohei AraiDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Eiichiro KandaDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan. tokyo.kyosai.kanda@gmail.com.
Soichiro IimoriDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Shotaro NaitoDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Yumi NodaDepartment of Nephrology, Nitobe Memorial Nakano General Hospital, Tokyo, Japan.
Tomoki KawasakiDepartment of Nephrology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan.
Hidehiko SatoDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Ryoichi AndoDepartment of Nephrology, Japanese Red Cross Musashino Hospital, Tokyo, Japan.
Sei SasakiDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Eisei SoharaDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Tomokazu OkadoDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Tatemitsu RaiDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Shinichi UchidaDepartment of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
Tokyo Medical and Dental University · JPMusashino Red Cross Hospital · JPNakano General Hospital · JPTokyo Metropolitan Ohtsuka Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D analogs have generally been recommended for treatment of mineral bone disease in chronic kidney disease (CKD). However, the association between this treatment and CKD progression has not yet been established.

methodsWe designed a post hoc propensity score-matched cohort analysis derived from 3-year follow-up data of a prospective cohort. Adult participants with pre-dialysis CKD stages 4-5 who had newly been prescribed active vitamin D analogs during the observation period were eligible as matched cases. Then, matched controls were extracted from participants who had never been prescribed active vitamin D analogs. The primary outcome was a composite of end-stage renal disease or a 50 % reduction in estimated glomerular filtration rate (eGFR). A Cox proportional hazards model evaluated the association between the use of vitamin D analogs and the primary outcome.

resultsWe enrolled 240 patients (males, 65 %). The number of matched cases and controls was 30 and 210, respectively. The primary outcome was observed in 94 patients, whereas 25 patients died. The mean ± standard deviation age and eGFR were 69 ± 12 years and 17 ± 5.7 ml/min/1.73 m

conclusionThe use of vitamin D analogs is independently associated with the preservation of renal function in patients with pre-dialysis CKD stages 4-5.

Indexed as

AgedAged, 80 and overCase-Control StudiesDisease ProgressionFemaleGlomerular Filtration RateHumansJapanKidneyKidney Failure, ChronicMaleMiddle AgedPropensity ScoreProportional Hazards ModelsProspective StudiesProtective FactorsVitamin DChronic kidney diseaseEnd-stage renal diseaseMineral bone diseaseVitamin D

Identifiers

PMID27344335
OpenAlexW2469284823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.