ArticleJournal of biomechanics2016
Prevalent role of porosity and osteonal area over mineralization heterogeneity in the fracture toughness of human cortical bone.
Article in Journal of biomechanics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Trial
- Proteoglycan Dynamics and Bone Quality: Molecular Regulation to Age-Related Fragility.Biomolecules · 2026Review
- Prediction of biomechanical properties of ex vivo human femoral cortical bone using Raman spectroscopy and machine learning algorithms.Bone reports · 2025Article
- Phase-field simulation of crack growth in cortical bone microstructure: parameter identification and comparison against experiments.Biomechanics and modeling in mechanobiology · 2025Article
- Microvascular disease not type 2 diabetes is associated with increased cortical porosity: A study of cortical bone microstructure and intracortical vessel characteristics.Bone reports · 2024Article
- Fracture Toughness: Bridging the Gap Between Hip Fracture and Fracture Risk Assessment.Current osteoporosis reports · 2023Review
- Accumulation of fluorescent advanced glycation end products and carboxymethyl-lysine in human cortical and trabecular bone.Bone reports · 2022Article
- Three-dimensional mapping of cortical porosity and thickness along the superolateral femoral neck in older women.Scientific reports · 2022Article
- Article
- Region-specific associations among tissue-level mechanical properties, porosity, and composition in human male femora.Journal of biomechanics · 2022Article
- Clinical Devices for Bone Assessment.Advances in experimental medicine and biology · 2022Review
- Article
- Poor bone matrix quality: What can be done about it?Current osteoporosis reports · 2021Review
- Article
- Cellular Processes by Which Osteoblasts and Osteocytes Control Bone Mineral Deposition and Maturation Revealed by Stage-Specific EphrinB2 Knockdown.Current osteoporosis reports · 2019Review
- Crack propagation in cortical bone is affected by the characteristics of the cement line: a parameter study using an XFEM interface damage model.Biomechanics and modeling in mechanobiology · 2019Article
- Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone.Scientific reports · 2019Article
- Bone collagen network integrity and transverse fracture toughness of human cortical bone.Bone · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Changes in the distribution of bone mineralization occurring with aging, disease, or treatment have prompted concerns that alterations in mineralization heterogeneity may affect the fracture resistance of bone. Yet, so far, studies assessing bone from hip fracture cases and fracture-free women have not reached a consensus on how heterogeneity in tissue mineralization relates to skeletal fragility. Owing to the multifactorial nature of toughening mechanisms occurring in bone, we assessed the relative contribution of heterogeneity in mineralization to fracture resistance with respect to age, porosity, and area fraction of osteonal tissue. The latter parameters were extracted from quantitative backscattered electron imaging of human cortical bone sections following R-curve tests of single-edge notched beam specimens to determine fracture toughness properties. Microstructural heterogeneity was determined as the width of the mineral distribution (bulk) and as the sill of the variogram (local). In univariate analyses of measures from 62 human donors (21 to 101 years), local but not bulk heterogeneity as well as pore clustering negatively correlated with fracture toughness properties. With age as covariate, heterogeneity was a significant predictor of crack initiation, though local had a stronger negative contribution than bulk. When considering all potential covariates, age, cortical porosity and area fraction of osteons explained up to 50% of the variance in bone׳s crack initiation toughness. However, including heterogeneity in mineralization did not improve upon this prediction. The findings of the present work stress the necessity to account for porosity and microstructure when evaluating the potential of matrix-related features to affect skeletal fragility.
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