ReviewSteroids2016
Effects of antenatal glucocorticoids on the developing brain.
Review in Steroids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Effects of antenatal corticosteroid therapy in animal models of fetal growth restriction: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Evaluation of Long-term Outcomes Associated With Preterm Exposure to Antenatal Corticosteroids: A Systematic Review and Meta-analysis.JAMA pediatrics · 2022Pooled it
- Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants.BMC medicine · 2021Trial
- Antenatal Late Preterm Steroids (ALPS): are we ready to accept it?Journal of perinatology : official journal of the California Perinatal Association · 2017Trial
- Executive function development between ages 2 and 6 in children exposed to threatened preterm labor.European child & adolescent psychiatry · 2026Article
- Impact of Antenatal Corticosteroids on Brain Function and Underlying Mechanisms in Preclinical Studies: Protocol for a Systematic Review.JMIR research protocols · 2026Article
- Association between timing of antenatal corticosteroid and developmental outcomes in children born late preterm by high-risk pregnancies.BMC pregnancy and childbirth · 2026Article
- Glycogen Synthase Kinase-3β Inhibitor VP3.15 Ameliorates Neurogenesis, Neuronal Loss and Cognitive Impairment in a Model of Germinal Matrix-intraventricular Hemorrhage of the Preterm Newborn.Translational stroke research · 2025Article
- Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain-Potential Triggers of Depressive Phenotype and Cognitive Impairment.Molecular neurobiology · 2025Article
- Opioid receptor signaling throughout ontogeny: Shaping neural and behavioral trajectories.Neuroscience and biobehavioral reviews · 2025Review
- Personalized Antenatal Corticosteroid Therapy and Central Nervous System Development: Reflections on the Gold Standard of Fetomaternal Therapy.Diseases (Basel, Switzerland) · 2024Review
- Neurohabilitation of Cognitive Functions in Pediatric Epilepsy Patients through LEGOBrain sciences · 2024Article
- Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs.Journal of neuroinflammation · 2024Article
- Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series).Pediatric research · 2024Review
- Lipid Rafts: The Maestros of Normal Brain Development.Biomolecules · 2024Review
- A pivotal role for the IL-1β and the inflammasome in preterm labor.Scientific reports · 2024Article
- Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (Microtus ochrogaster).Molecular and cellular endocrinology · 2023Article
- An update on the long-term outcomes of prenatal dexamethasone treatment in congenital adrenal hyperplasia.Endocrine connections · 2023Review
- ABCB1 expression is increased in human first trimester placenta from pregnant women classified as overweight or obese.Scientific reports · 2023Article
- The role of antenatal corticosteroids in twin pregnancy.Frontiers in pharmacology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Glucocorticoids (GCs) regulate distinct physiological processes in the developing fetus, in particular accelerating organ maturation that enables the fetus to survive outside the womb. In preterm birth, the developing fetus does not receive sufficient exposure to endogenous GCs in utero for proper organ development predisposing the neonate to complications including intraventricular hemorrhage, respiratory distress syndrome (RDS) and necrotizing enterocolitis (NEC). Synthetic GCs (sGCs) have proven useful in the prevention of these complications since they are able to promote the rapid maturation of underdeveloped organs present in the fetus. While these drugs have proven to be clinically effective in the prevention of IVH, RDS and NEC, they may also trigger adverse developmental side effects. This review will examine the current clinical use of antenatal sGC therapy in preterm birth, their placental metabolism, and their effects on the developing brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.