ArticleAmerican journal of physiology. Lung cellular and molecular physiology2016
Brief mechanical ventilation causes differential epithelial repair along the airways of fetal, preterm lambs.
Article in American journal of physiology. Lung cellular and molecular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Changes in mucin expression in the lungs of infant piglets following cardiopulmonary bypass with deep hypothermic circulatory arrest.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2026Article
- Postnatal budesonide improved lung function in preterm lambs exposed to antenatal steroids and chorioamnionitis.Pediatric research · 2024Article
- Preterm lung and brain responses to mechanical ventilation and corticosteroids.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells.Respiratory research · 2023Article
- Preterm ovine respiratory epithelial cell responses to mechanical ventilation, lipopolysaccharide, and interleukin-13.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Influence of SARS-CoV-2 on airway mucus production: A review and proposed model.Veterinary pathology · 2022Review
- Ventilation-Induced Lung Injury (VILI) in Neonates: Evidence-Based Concepts and Lung-Protective Strategies.Journal of clinical medicine · 2022Review
- Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero.Pediatric research · 2021Article
- Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.American journal of respiratory and critical care medicine · 2019Article
- Gestational Age Influences the Early Microarchitectural Changes in Response to Mechanical Ventilation in the Preterm Lamb Lung.Frontiers in pediatrics · 2019Article
- Plasma proteomics reveals gestational age-specific responses to mechanical ventilation and identifies the mechanistic pathways that initiate preterm lung injury.Scientific reports · 2018Article
- Effects of budesonide and surfactant in preterm fetal sheep.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Mechanical ventilation of preterm lambs causes lung inflammation and injury to the airway epithelium, which is repaired by 15 days after ventilation. In mice, activated basal cells (p63+, KRT14+, KRT8+) initiate injury repair to the trachea, whereas club cells coordinate distal airway repair. In both human and sheep, basal cells line the pseudostratified airways to the distal bronchioles with club cells only present in terminal bronchioles. Mechanical ventilation causes airway epithelial injury that is repaired through basal cell activation in the fetal lung. Ewes at 123 ± 1 day gestational age had the head and chest of the fetus exteriorized and tracheostomy placed. With placental circulation intact, fetal lambs were mechanically ventilated with up to 15 ml/kg for 15 min with 95% N2/5% CO2 Fetal lambs were returned to the uterus for up to 24 h. The trachea, left mainstem bronchi, and peripheral lung were evaluated for epithelial injury and cellular response consistent with repair. Peripheral lung tissue had inflammation, pro-inflammatory cytokine production, epithelial growth factor receptor ligand upregulation, increased p63 expression, and proliferation of pro-SPB, TTF-1 positive club cells. In bronchi, KRT14 and KRT8 mRNA increased without increases in Notch pathway mRNA or proliferation. In trachea, mRNA increased for Notch ligands, SAM pointed domain-containing Ets transcription factor and mucin 5B, but not for basal cell markers. A brief period of mechanical ventilation causes differential epithelial activation between trachea, bronchi, and peripheral lung. The repair mechanisms identified in adult mice occur at different levels of airway branching in fetal sheep with basal and club cell activation.
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