ArticleProceedings of the National Academy of Sciences of the United States of America1989
Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 219 citations in OpenAlex.
- Transcriptome analysis of dog oral melanoma and its oncogenic analogy with human melanoma.Oncology reports · 2020Article
- Liquid Biopsies for Assessing Metastatic Melanoma Progression.Critical reviews in oncogenesis · 2016Review
- The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.Gene expression patterns : GEP · 2013Article
- p73-Binding Partners and Their Functional Significance.International journal of proteomics · 2010Article
- Article
- Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36.Oncogene · 2002Article
- Molecular clonality of in-transit melanoma metastasis.The American journal of pathology · 2001Article
- TTC4, a novel candidate tumor suppressor gene at 1p31 is often mutated in malignant melanoma of the skin.Oncogene · 2000Article
- Allelic loss of the region of chromosome 1p35-pter is associated with progression of human gastric carcinoma.Japanese journal of cancer research : Gann · 2000Article
- Association of specific chromosome alterations with tumour phenotype in posterior uveal melanoma.British journal of cancer · 2000Article
- Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target.Oncogene · 1999Article
- Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations.British journal of cancer · 1999Article
- Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival.British journal of cancer · 1999Article
- Thymic carcinoids in multiple endocrine neoplasia type 1.Annals of surgery · 1998Article
- MYCL genotypes and loss of heterozygosity in non-small-cell lung cancer.British journal of cancer · 1996Article
- Chromosome 6 trisomy as sole anomaly in a primary Merkel cell carcinoma.Virchows Archiv : an international journal of pathology · 1996Article
- A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.Journal of medical genetics · 1996Article
- Detection of chromosome aberrations in paraffin sections of seven gonadal yolk sac tumors of childhood.Human genetics · 1995Article
- PITSLRE protein kinase activity is associated with apoptosis.Molecular and cellular biology · 1995Article
- Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p.The American journal of pathology · 1994Article
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7 authors at 2 institutions in 1 country.
Funding
Abstract
The gene for familial malignant melanoma and its precursor lesion, the dysplastic nevus, has been assigned to a region of the distal short arm of chromosome 1, which is frequently involved in karyotypic abnormalities in melanoma cells. We have examined loci on chromosome 1p for loss-of-constitutional heterozygosity in 35 melanomas and 21 melanoma cell lines to analyze the role of these abnormalities in melanocyte transformation. Loss-of-heterozygosity at loci on chromosome 1p was identified in 15/35 (43%) melanomas and 11/21 (52%) melanoma cell lines. Analysis of multiple metastases derived from the same patient and of melanoma and lymphoblastoid samples from a family with hereditary melanoma showed that the loss-of-heterozygosity at loci on distal 1p is a late event in tumor progression, rather than the second mutation that would occur if melanoma were due to a cellular recessive mechanism. Comparisons with neuroblastoma and multiple endocrine neoplasia (MEN2) suggest that the frequent 1p loss-of-heterozygosity in these malignancies is a common late event of neuroectodermal tumor progression.
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