ReviewAdvances in experimental medicine and biology2016
Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation.
Review in Advances in experimental medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues.Nature communications · 2024Article
- Adaptive structural and functional evolution of the placenta protects fetal growth in high-elevation deer mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Parallel genomic responses to historical climate change and high elevation in East Asian songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Fetal growth, high altitude, and evolutionary adaptation: a new perspective.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Article
- High-Altitude Adaptation: Mechanistic Insights from Integrated Genomics and Physiology.Molecular biology and evolution · 2021Review
- Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice.The Journal of heredity · 2021Article
- High-altitude rodents have abundant collaterals that protect against tissue injury after cerebral, coronary and peripheral artery occlusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Physiological Genomics of Adaptation to High-Altitude Hypoxia.Annual review of animal biosciences · 2021Review
- Phenotypic plasticity as a long-term memory easing readaptations to ancestral environments.Science advances · 2020Article
- Regulation of catecholamine release from the adrenal medulla is altered in deer mice (American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Evolution of physiological performance capacities and environmental adaptation: insights from high-elevation deer mice (Journal of mammalogy · 2019Article
- Whole-genome de novo sequencing reveals unique genes that contributed to the adaptive evolution of the Mikado pheasant.GigaScience · 2018Article
- Nature's fat-burning machine: brown adipose tissue in a hibernating mammal.The Journal of experimental biology · 2018Review
- Migration-Selection Balance Drives Genetic Differentiation in Genes Associated with High-Altitude Function in the Speckled Teal (Anas flavirostris) in the Andes.Genome biology and evolution · 2018Article
- Review
Corrections and comments
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2 authors.
Funding
Abstract
Recent studies of indigenous human populations at high altitude have provided proof-of-principle that genome scans of DNA polymorphism can be used to identify candidate loci for hypoxia adaptation. When integrated with experimental analyses of physiological phenotypes, genome-wide surveys of DNA polymorphism and tissue-specific transcriptional profiles can provide insights into actual mechanisms of adaptation. It has been suggested that adaptive phenotypic evolution is largely mediated by cis-regulatory changes in genes that are located at integrative control points in regulatory networks. This hypothesis can be tested by conducting transcriptomic analyses of hypoxic signaling pathways in conjunction with experimental measures of vascular oxygen supply and metabolic pathway flux. Such studies may reveal whether the architecture of gene regulatory networks can be used to predict which loci (and which types of loci) are likely to be "hot spots" for adaptive physiological evolution. Functional genomic studies of deer mice (Peromyscus maniculatus) demonstrate how the integrated analysis of variation in tissue-specific transcriptomes, whole-animal physiological performance, and various subordinate traits can yield insights into the mechanistic underpinnings of high-altitude adaptation.
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