SynthesisWorld journal of surgery2016
Autologous but not Fibrin Sealant Patches for Stump Coverage Reduce Clinically Relevant Pancreatic Fistula in Distal Pancreatectomy: A Systematic Review and Meta-analysis.
Synthesis in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery.The Cochrane database of systematic reviews · 2023Pooled it
- Efficacy of Fibrin Sealant in Reducing Complication Risk After Bariatric Surgery: a Systematic Review and Meta-analysis.Obesity surgery · 2021Pooled it
- Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery.The Cochrane database of systematic reviews · 2020Pooled it
- Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery.The Cochrane database of systematic reviews · 2018Pooled it
- "The Critical 18" of postoperative white blood cell count and C-reactive protein level predicts postoperative pancreatic fistula after distal pancreatectomy.Patient safety in surgery · 2026Article
- Prediction of Postoperative Pancreatic Fistula Occurrence by the Pancreatic Stump Shape and Remnant Pancreatic Volume Measured Using AI-Guided Three-Dimensional Simulation.Annals of surgical oncology · 2026Article
- Review
- Postoperative Opioid Use Is Associated with Increased Rates of Grade B/C Pancreatic Fistula After Distal Pancreatectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Autologous transplantation of multilayered fibroblast sheets prevents postoperative pancreatic fistula by regulating fibrosis and angiogenesis.American journal of translational research · 2021Article
- Modified Reinforced Staple Closure Technique Decreases Postoperative Pancreatic Fistula After Distal Pancreatectomy.Indian journal of surgical oncology · 2019Article
- Optimizing the outcomes of pancreatic cancer surgery.Nature reviews. Clinical oncology · 2019Review
- Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model.Scientific reports · 2018Article
- Postoperative pancreatic fistula: a review of traditional and emerging concepts.Clinical and experimental gastroenterology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative pancreatic fistula (POPF) causes significant morbidity and mortality after distal pancreatectomy. Patch coverage of the pancreatic stump is often used with the intention to prevent POPF. Despite numerous investigations, the effects of patch coverage remain unclear. The present meta-analysis aims to clarify the effects of patch coverage in distal pancreatectomy on the incidence of POPF.
methodsA systematic search of MEDLINE/PubMed and the Cochrane Database according to the PRISMA Statement was performed. Subsequently a meta-analysis on rates and overall incidence of POPF and length of hospital stay was carried out. By applying the inverse variance weighting method, the combined effect size and 95 % confidence interval were calculated. Heterogeneity was assessed using I
resultsFive randomized controlled trials and six observational clinical studies were included for final analysis. A cumulative incidence of 43 % of POPF grades A-C was identified. Patch coverage in distal pancreatectomy is significantly associated with a decreased rate of POPF grade C (p = 0.006). Patches of autologous vascularized tissue significantly reduce the overall incidence of POPF (p = 0.04) and clinically relevant POPF grade B and C (p = 0.002). Fibrin sealant patches do not influence rates of POPF after distal pancreatectomy. None of the outcomes evaluated showed adverse results for the patch group.
conclusionsPatch coverage after distal pancreatectomy can reduce the rate of POPF. Patch coverage with autologous vascularized tissue but not fibrin sealant patches may be used to reduce clinically relevant POPF and postoperative morbidity in distal pancreatectomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.