Trial reportFASEB journal : official publication of the Federation of American Societies for Experimental Biology2016
Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.
Trial report in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days.Nutrients · 2020Pooled it
- Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.The American journal of clinical nutrition · 2026Trial
- Genetic Variants in One-Carbon Metabolism and Their Effects on DHA Biomarkers in Pregnant Women: A Post-Hoc Analysis.Nutrients · 2022Trial
- Prenatal choline supplementation improves biomarkers of maternal docosahexaenoic acid (DHA) status among pregnant participants consuming supplemental DHA: a randomized controlled trial.The American journal of clinical nutrition · 2022Trial
- Choline metabolome response to prenatal choline supplementation across pregnancy: A randomized controlled trial.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Trial
- Reproductive state and choline intake influence enrichment of plasma lysophosphatidylcholine-DHA: aThe British journal of nutrition · 2019Trial
- Development of a Choline Database for Thai Food and a Population-Wide Assessment of Choline Intake in Thailand.Nutrients · 2026Article
- Article
- Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant.The Journal of nutrition · 2025Article
- Choline-Mediated Regulation of Follicular Growth: Interplay Between Steroid Synthesis, Epigenetics, and Oocyte Development.Biology · 2025Review
- Nutrients as epigenetic modulators in metabolic dysfunction-associated steatotic liver disease.World journal of hepatology · 2025Review
- Perinatal nutrition as a key regulator of genomic imprinting: a new paradigm for maternal-child health.Frontiers in nutrition · 2025Article
- The distribution of dietary choline intake and serum choline levels in Australian women during pregnancy and associated early life factors.European journal of nutrition · 2023Article
- Choline - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
- Review
- Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation.Nutrients · 2022Review
- Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice.Nutrients · 2021Article
- Ceramide synthase 6 mediates sex-specific metabolic response to dietary folic acid in mice.The Journal of nutritional biochemistry · 2021Article
- Polymorphisms in SLC44A1 are associated with cognitive improvement in children diagnosed with fetal alcohol spectrum disorder: an exploratory study of oral choline supplementation.The American journal of clinical nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 1 institution in 1 country.
Funding
Abstract
Although single nucleotide polymorphisms (SNPs) in folate-mediated pathways predict susceptibility to choline deficiency during severe choline deprivation, it is unknown if effects persist at recommended intakes. Thus, we used stable isotope liquid chromatography-mass spectrometry (LC-MS) methodology to examine the impact of candidate SNPs on choline metabolism in a long-term, randomized, controlled feeding trial among pregnant, lactating, and nonpregnant (NP) women consuming 480 or 930 mg/d choline (22% as choline-d
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.