Evidence map›Paper›PMID 27342751›Full record

ArticleBioorganic & medicinal chemistry letters2016

Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.

Kayla J Temple, Elia N Wright, Carol A Fierke, Richard A Gibbs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kayla J TempleDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA; The Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47909, USA. Electronic address: kayla.temple@vanderbilt.edu.
Elia N WrightDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Carol A FierkeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Richard A GibbsDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA; The Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47909, USA.
Purdue University West Lafayette · USUniversity of Michigan–Ann Arbor · US

Funding

STRUCTURE/FUNCTION OF ZINC METALLOPROTEINSR01GM040602 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FIERKE, CAROL A · 1993 to 2017
$6.0M
CHEMICAL PROBES OF PROTEIN PRENYLATIONR01CA078819 · NCI · WAYNE STATE UNIVERSITY · PI GIBBS, RICHARD A · 1998 to 2007
$1.1M
NCI NIH HHS R01 CA078819NIGMS NIH HHS R01 GM040602
6 · The paper itself

Abstract

Protein prenylation is a type of post-translational modification that aids certain proteins in localizing to the plasma member where they activate cell signaling. To better understand the isoprenoid requirements and differences of FTase and GGTase-I, a series of saturated geranylgeranyl diphosphate analogs were synthesized and screened against both mammalian FTase and GGTase-I. Of our library of compounds, several analogs proved to be substrates of GGTase-I, with 11d having a krel=0.95 when compared to GGPP (krel=1.0).

Indexed as

Alkyl and Aryl TransferasesDose-Response Relationship, DrugHumansMolecular StructurePolyisoprenyl PhosphatesStructure-Activity RelationshipAlkyl and Aryl Transferasesgeranylgeranyl pyrophosphategeranylgeranyltransferase type-IPolyisoprenyl PhosphatesFarnesylationGeranylgeranylationIsoprenoid synthesisProtein prenylationSaturated GGPP analogs

Identifiers

PMID27342751
PMCPMC4955811
OpenAlexW2431152791

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.