Evidence map›Paper›PMID 27342577›Full record

ArticleJournal of child neurology2016

The Relation of Focal Lesions to Cortical Thickness in Pediatric Traumatic Brain Injury.

Erin D Bigler, Brandon A Zielinski, Naomi Goodrich-Hunsaker, Garrett M Black, B S Trevor Huff, Zachary Christiansen, Dawn-Marie Wood, Tracy J Abildskov, Maureen Dennis, H Gerry Taylor and 5 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 2 countries.

Erin D BiglerDepartment of Psychology and the Neuroscience Center, Brigham Young University, Provo, UT, USA Department of Psychiatry, University of Utah, Salt Lake City, UT, USA erin_bigler@byu.edu.
Brandon A ZielinskiDepartments of Pediatrics and Neurology, University of Utah, Salt Lake City, UT, USA.
Naomi Goodrich-HunsakerDepartment of Psychology, Brigham Young University, Provo, UT, USA.
Garrett M BlackDepartment of Psychology, Brigham Young University, Provo, UT, USA.
B S Trevor HuffDepartment of Psychology, Brigham Young University, Provo, UT, USA.
Zachary ChristiansenDepartment of Psychology, Brigham Young University, Provo, UT, USA.
Dawn-Marie WoodDepartment of Psychology, Brigham Young University, Provo, UT, USA.
Tracy J AbildskovDepartment of Psychology, Brigham Young University, Provo, UT, USA.
Maureen DennisProgram in Neuroscience & Mental Health, The Hospital for Sick Children, Toronto, Canada Department of Surgery and Department of Psychology, University of Toronto, Toronto, Canada.
H Gerry TaylorDepartment of Pediatrics, Case Western Reserve University and Rainbow Babies & Children's Hospital, University Hospitals Case Medical Center, Cleveland, OH, USA.
Kenneth RubinDepartment of Psychology, University of Maryland, College Park, MD, USA.
Kathryn VannattaDepartment of Pediatrics, The Ohio State University, Columbus, OH, USA Center for Behavioral Health, Columbus Children's Research Institute, Columbus, OH, USA.
Cynthia A GerhardtDepartment of Pediatrics, The Ohio State University, Columbus, OH, USA Center for Behavioral Health, Columbus Children's Research Institute, Columbus, OH, USA.
Terry StancinDepartment of Pediatrics, Case Western Reserve University and Rainbow Babies & Children's Hospital, University Hospitals Case Medical Center, Cleveland, OH, USA Department of Psychiatry, MetroHealth Medical Center, Cleveland, OH, USA.
Keith Owen YeatesDepartment of Pediatrics, The Ohio State University, Columbus, OH, USA Center for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Brigham Young University · USCase Western Reserve University · USInstitute for Behavioral Medicine · USNationwide Children's Hospital · USThe Ohio State University · USUniversity Hospitals Case Medical Center · USUniversity of Maryland, College Park · USUniversity of Toronto · CAUniversity of Utah · US

Funding

Social Outcomes in Pediatric Traumatic Brain InjuryR01HD048946 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI YEATES, KEITH O · 2006 to 2010
$4.3M
Brain Network Development in Normal and Autistic ChildrenK08MH100609 · NIMH · UNIVERSITY OF UTAH · PI ZIELINSKI, BRANDON A. · 2014 to 2017
$759k
NICHD NIH HHS R01 HD048946NIMH NIH HHS K08 MH100609
6 · The paper itself

Abstract

In a sample of children with traumatic brain injury, this magnetic resonance imaging (MRI)-based investigation examined whether presence of a focal lesion uniquely influenced cortical thickness in any brain region. Specifically, the study explored the relation of cortical thickness to injury severity as measured by Glasgow Coma Scale score and length of stay, along with presence of encephalomalacia, focal white matter lesions or presence of hemosiderin deposition as a marker of shear injury. For comparison, a group of children without head injury but with orthopedic injury of similar age and sex were also examined. Both traumatic brain injury and orthopedic injury children had normally reduced cortical thickness with age, assumed to reflect neuronal pruning. However, the reductions observed within the traumatic brain injury sample were similar to those in the orthopedic injury group, suggesting that in this sample traumatic brain injury, per se, did not uniquely alter cortical thickness in any brain region at the group level. Injury severity in terms of Glasgow Coma Scale or longer length of stay was associated with greater reductions in frontal and occipitoparietal cortical thickness. However, presence of focal lesions were not related to unique changes in cortical thickness despite having a prominent distribution of lesions within frontotemporal regions among children with traumatic brain injury. Because focal lesions were highly heterogeneous, their association with cortical thickness and development appeared to be idiosyncratic, and not associated with group level effects.

Indexed as

Brain Injuries, TraumaticCerebral CortexChildChronic DiseaseEncephalomalaciaFemaleGlasgow Coma ScaleHemosiderinHumansLength of StayMagnetic Resonance ImagingMaleOrgan SizeWhite MatterHemosiderinbrain developmentcortical thicknesslesion analysispediatric traumatic brain injury

Identifiers

PMID27342577
PMCPMC5525324
OpenAlexW2463555264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.