ArticleJournal of experimental botany2016
Silencing of ABCC13 transporter in wheat reveals its involvement in grain development, phytic acid accumulation and lateral root formation.
Article in Journal of experimental botany, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 126 citations in OpenAlex.
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- Multi-locus GWAS to unravel the genetic architecture of grain iron, zinc and protein contents in wheat (Triticum aestivum L.) genotypes evaluated over multiple locations and years.BMC plant biology · 2026Article
- Functional Genetic Frontiers in Plant ABC Transporters: Avenues Toward Cadmium Management.International journal of molecular sciences · 2025Review
- Ameliorative effects of strigolactone on tolerance to lead stress on lettuce (Lactuca sativa L.) plants.Scientific reports · 2025Article
- Identification of candidate genes for grain size in barley through combined GWAS and transcriptome analysis.Journal of plant research · 2025Article
- Spatiotemporal transcriptomics reveals key gene regulation for grain yield and quality in wheat.Genome biology · 2025Article
- Micronutrient Biofortification in Wheat: QTLs, Candidate Genes and Molecular Mechanism.International journal of molecular sciences · 2025Review
- Biotechnological approaches to reduce the phytic acid content in millets to improve nutritional quality.Planta · 2024Review
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- The Uptake, Transfer, and Detoxification of Cadmium in Plants and Its Exogenous Effects.Cells · 2024Review
- Genetic biofortification: advancing crop nutrition to tackle hidden hunger.Functional & integrative genomics · 2024Review
- Identification and expression analysis of ATP-binding cassette (ABC) transporters revealed its role in regulating stress response in pear (Pyrus bretchneideri).BMC genomics · 2024Article
- An Overview of Targeted Genome Editing Strategies for Reducing the Biosynthesis of Phytic Acid: an Anti-nutrient in Crop Plants.Molecular biotechnology · 2024Review
- Advancements in genome editing tools for genetic studies and crop improvement.Frontiers in plant science · 2024Review
- Critical assessment of wheat biofortification for iron and zinc: a comprehensive review of conceptualization, trends, approaches, bioavailability, health impact, and policy framework.Frontiers in nutrition · 2023Review
- The suppression of TdMRP3 genes reduces the phytic acid and increases the nutrient accumulation in durum wheat grain.Frontiers in plant science · 2023Article
- Wheat Selenium-binding protein TaSBP-A enhances cadmium tolerance by decreasing free CdFrontiers in plant science · 2023Article
- Advances in Genes-Encoding Transporters for Cadmium Uptake, Translocation, and Accumulation in Plants.Toxics · 2022Review
- Article
- Genomic approaches for improving grain zinc and iron content in wheat.Frontiers in genetics · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low phytic acid is a trait desired in cereal crops and can be achieved by manipulating the genes involved either in its biosynthesis or its transport in the vacuoles. Previously, we have demonstrated that the wheat TaABCC13 protein is a functional transporter, primarily involved in heavy metal tolerance, and a probable candidate gene to achieve low phytate wheat. In the current study, RNA silencing was used to knockdown the expression of TaABCC13 in order to evaluate its functional importance in wheat. Transgenic plants with significantly reduced TaABCC13 transcripts in either seeds or roots were selected for further studies. Homozygous RNAi lines K1B4 and K4G7 exhibited 34-22% reduction of the phytic acid content in the mature grains (T4 seeds). These transgenic lines were defective for spike development, as characterized by reduced grain filling and numbers of spikelets. The seeds of transgenic wheat had delayed germination, but the viability of the seedlings was unaffected. Interestingly, early emergence of lateral roots was observed in TaABCC13-silenced lines as compared to non-transgenic lines. In addition, these lines also had defects in metal uptake and development of lateral roots in the presence of cadmium stress. Our results suggest roles of TaABCC13 in lateral root initiation and enhanced sensitivity towards heavy metals. Taken together, these data demonstrate that wheat ABCC13 is functionally important for grain development and plays an important role during detoxification of heavy metals.
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