Evidence map›Paper›PMID 27342121›Full record

ArticleMagnetic resonance in medicine2017

Rapid measurement of brain macromolecular proton fraction with transient saturation transfer MRI.

Peter van Gelderen, Xu Jiang, Jeff H Duyn

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
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  11. Creatine mapping of the brain at 3T by CEST MRI.Magnetic resonance in medicine · 2024
    Article
  12. Review
  13. Article
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  17. Review
  18. Data-Driven Retrospective Correction of BIEEE transactions on medical imaging · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Peter van GelderenAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Xu JiangAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Jeff H DuynAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

Funding

Magnetic Resonance Imaging of Human Brain Anatomy and FunctionZIANS003027 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI DUYN, JEFF · 2009 to 2025
$31.2M
Magnetic Resonance Imaging Technology DevelopmentZIANS002990 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI DUYN, JEFF · 2009 to 2025
$25.5M
Magnetic Resonance Imaging Technology DevelopmentZ01NS002990 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI DUYN, JOZEF H · 2000 to 2008
$2.4M
Intramural NIH HHS Z01 NS002990
6 · The paper itself

Abstract

purposeTo develop an efficient MRI approach to estimate the nonwater proton fraction (f) in human brain.

methodsWe implement a brief, efficient magnetization transfer (MT) pulse that selectively saturates the magnetization of the (semi-) solid protons, and monitor the transfer of this saturation to the water protons as a function of delay after saturation.

resultsAnalysis of the transient MT effect with two-pool model allowed robust extraction of f at both 3 and 7 T. This required estimating the longitudinal relaxation rate constant (R

conclusionExperiments performed on human brain in vivo at 3 and 7 T demonstrate the ability of the method to robustly determine f in a scan time of approximately 5 min. Magn Reson Med 77:2174-2185, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

Signal Processing, Computer-AssistedAdultAlgorithmsBrainHumansImage EnhancementImage Interpretation, Computer-AssistedMacromolecular SubstancesMagnetic Resonance ImagingMiddle AgedMolecular ImagingMyelin SheathProton Magnetic Resonance SpectroscopyReproducibility of ResultsSensitivity and SpecificityTissue DistributionMacromolecular Substancesbrain tissuemacromolecular proton fractionmagnetization transfermyelinT1 relaxationwhite matter

Identifiers

PMID27342121
PMCPMC5183566

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.