ArticleReproductive biology and endocrinology : RB&E2016
Preimplantation genetic screening- the required RCT that has not yet been carried out.
Article in Reproductive biology and endocrinology : RB&E, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- PGT-A: who and when? Α systematic review and network meta-analysis of RCTs.Journal of assisted reproduction and genetics · 2021Pooled it
- Preimplantation genetic testing for aneuploidy on previously cryopreserved unbiopsied blastocysts: a cohort study in women with IVF pregnancy loss.Reproductive biology and endocrinology : RB&E · 2025Observational
- Hysteroscopic Endometrial Fundal Incision in Oocyte Recipients before Embryo Transfer May Improve Reproductive Outcomes: A Prospective Study.International journal of fertility & sterility · 2023Article
- Revisiting selected ethical aspects of current clinical in vitro fertilization (IVF) practice.Journal of assisted reproduction and genetics · 2022Review
- Analysis of vaginal and endometrial microbiota communities in infertile women with a history of repeated implantation failure.Reproductive medicine and biology · 2021Article
- Article
- Relationship between age and blastocyst chromosomal ploidy analyzed by noninvasive preimplantation genetic testing for aneuploidies (niPGT-A).JBRA assisted reproduction · 2020Article
- Healthy live births from transfer of low-mosaicism embryos after preimplantation genetic testing for aneuploidy.Journal of assisted reproduction and genetics · 2020Article
- Preimplantation genetic testing for aneuploidy (PGT-A)-finally revealed.Journal of assisted reproduction and genetics · 2020Article
- A tale of two studies: now is no longer the best of times for preimplantation genetic testing for aneuploidy (PGT-A).Journal of assisted reproduction and genetics · 2020Article
- Does preimplantation genetic testing for aneuploidy really improve IVF outcomes in advanced maternal age patients without compromising cumulative live-birth rate?Journal of assisted reproduction and genetics · 2020Article
- Article
- Should We Offer In Vitro Fertilization to Couples with Unexplained Recurrent Pregnancy Loss?Journal of clinical medicine · 2019Review
- New perspectives with the use of noninvasive chromosome screening (NICS) in ART.JBRA assisted reproduction · 2019Article
- Lessons from the premature adoption of preimplantation embryo testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Preimplantation Genetic Diagnosis of Neurodegenerative Diseases: Review of Methodologies and Report of Our Experience as a Regional Reference Laboratory.Diagnostics (Basel, Switzerland) · 2019Article
- The cost of a euploid embryo identified from preimplantation genetic testing for aneuploidy (PGT-A).Journal of assisted reproduction and genetics · 2018Article
- Genetic counseling prior to Assisted Reproductive Technology procedures in the era of cytogenomics.JBRA assisted reproduction · 2018Article
- Degree of mosaicism in trophectoderm does not predict pregnancy potential: a corrected analysis of pregnancy outcomes following transfer of mosaic embryos.Reproductive biology and endocrinology : RB&E · 2018Article
- Expression of E2A in mid-secretory endometrium of women suffering from recurrent miscarriage.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The utilization of trophectoderm biopsy combined with comprehensive chromosome screening (CCS) tests for embryonic aneuploidy was recently suggested to improve IVF outcome, however, not without criticisms. The ongoing discussion on the unrestricted clinical adoption of preimplantation genetic screening (PGS) has called for a proper randomized controlled trial (RCT), aiming to further evaluate the cumulative live birth rates (LBRs) following a single oocyte retrieval, utilizing all fresh and frozen embryos. Since this study seems not to appear for various reasons, we present herewith, the hypothetical required RCT based on the hitherto published literature.After implementing data from the hitherto published literature on blastulation and aneuploidy rates, the rate of mosaicism and technical errors and implantation rates/LBRs of non-PGS day-3 and blastocyst and PGS blastocyst, we could clearly demonstrate the superiority of non-PGS embryo (day-3 and blastocyst) transfer over PGS blastocyst transfer, in terms of cumulative LBR (18.2-50 % vs 7.6-12.6 %, respectively).We therefore believe that until the proper, non-hypothetical RCT on the efficacy of this procedure will appear, PGS should be offered only under study conditions, and with appropriate informed consents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.