ArticlePLoS genetics2016
TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Cracking the fertility code: a comprehensive review of biomarkers and functional measures.Open biology · 2026Review
- Gene regulatory networks orchestrating oocyte fate bifurcation in primordial follicles revealed by single-cell transcriptomics.Communications biology · 2026Article
- Coordinating meiotic prophase I progression and early oocyte differentiation.Development (Cambridge, England) · 2026Article
- Article
- Effect of Brief Maternal Exposure to Bisphenol A on the Fetal Female Germline in a Mouse Model.Environmental health perspectives · 2025Article
- Research advances in the construction of stem cell-derived ovarian organoids.Stem cell research & therapy · 2024Review
- Whole-exome sequencing and Drosophila modelling reveal mutated genes and pathways contributing to human ovarian failure.Reproductive biology and endocrinology : RB&E · 2024Article
- Genomic landscape of diploid and aneuploid microsatellite stable early onset colorectal cancer.Scientific reports · 2024Article
- Regulation of Oocyte mRNA Metabolism: A Key Determinant of Oocyte Developmental Competence.Advances in anatomy, embryology, and cell biology · 2024Review
- Partial cytological diploidization of neoautotetraploid meiosis by induced cross-over rate reduction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cell cycle regulation for meiosis in mammalian germ cells.The Journal of reproduction and development · 2023Review
- SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I.BMC biology · 2023Article
- Transcription and chromatin regulation by TAF4b during cellular quiescence of developing prospermatogonia.Frontiers in cell and developmental biology · 2023Article
- TAF4b transcription networks regulating early oocyte differentiation.Development (Cambridge, England) · 2022Article
- Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation.Aging cell · 2021Article
- FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation.Nucleic acids research · 2020Article
- ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis.Molecular and cellular biology · 2020Article
- Dynamic and regulated TAF gene expression during mouse embryonic germ cell development.PLoS genetics · 2020Article
- Genetic diagnosis of subfertility: the impact of meiosis and maternal effects.Journal of medical genetics · 2019Review
- Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice.eLife · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
TAF4b is a gonadal-enriched subunit of the general transcription factor TFIID that is implicated in promoting healthy ovarian aging and female fertility in mice and humans. To further explore the potential mechanism of TAF4b in promoting ovarian follicle development, we analyzed global gene expression at multiple time points in the human fetal ovary. This computational analysis revealed coordinate expression of human TAF4B and critical regulators and effectors of meiosis I including SYCP3, YBX2, STAG3, and DAZL. To address the functional relevance of this analysis, we turned to the embryonic Taf4b-deficient mouse ovary where, for the first time, we demonstrate, severe deficits in prophase I progression as well as asynapsis in Taf4b-deficient oocytes. Accordingly, TAF4b occupies the proximal promoters of many essential meiosis and oogenesis regulators, including Stra8, Dazl, Figla, and Nobox, and is required for their proper expression. These data reveal a novel TAF4b function in regulating a meiotic gene expression program in early mouse oogenesis, and support the existence of a highly conserved TAF4b-dependent gene regulatory network promoting early oocyte development in both mice and women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.