ReviewCurrent opinion in nephrology and hypertension2016
Calcium channels in primary cilia.
Review in Current opinion in nephrology and hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Hyperosmolality activates polycystin-2 and TRPM4 in renal primary cilium.Pflugers Archiv : European journal of physiology · 2025Article
- Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling.Journal of cellular physiology · 2025Article
- Article
- Mechanobiology in cellular, molecular, and tissue adaptation.Mechanobiology in medicine · 2023Article
- Primary cilia as dynamic and diverse signalling hubs in development and disease.Nature reviews. Genetics · 2023Review
- Cilia in the Striatum Mediate Timing-Dependent Functions.Molecular neurobiology · 2023Article
- The Primary Cilium and Neuronal Migration.Cells · 2022Review
- Islet primary cilia motility controls insulin secretion.Science advances · 2022Article
- Subtype-Selective Positive Modulation of KACS chemical biology · 2022Article
- Primary cilia in satellite cells are the mechanical sensors for muscle hypertrophy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Fluorescence imaging of beta cell primary cilia.Frontiers in endocrinology · 2022Article
- Islet cilia and glucose homeostasis.Frontiers in cell and developmental biology · 2022Review
- Mechanisms underlying unidirectional laminar shear stress-mediated Nrf2 activation in endothelial cells: Amplification of low shear stress signaling by primary cilia.Redox biology · 2021Review
- Patterns of cilia gene dysregulations in major psychiatric disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Ciliopathic micrognathia is caused by aberrant skeletal differentiation and remodeling.Development (Cambridge, England) · 2021Article
- Primary Cilia and Calcium Signaling Interactions.International journal of molecular sciences · 2020Review
- Adhesion GPCRs as a paradigm for understanding polycystin-1 G protein regulation.Cellular signalling · 2020Review
- Primary cilia control glucose homeostasis via islet paracrine interactions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Primary cilia: Versatile regulator in cartilage development.Cell proliferation · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewPrimary cilia have become important organelles implicated in embryonic development, organogenesis, health, and diseases. Although many studies in cell biology have focused on changes in ciliary length or ciliogenesis, the most common readout for evaluating ciliary function is intracellular calcium. RECENT
findingsRecent tools have allowed us to examine intracellular calcium in more precise locations, that is, the cilioplasm and cytoplasm. Advances in calcium imaging have also allowed us to identify which cilia respond to particular stimuli. Furthermore, direct electrophysiological measurement of ionic currents within a cilium has provided a wealth of information for understanding the sensory roles of primary cilia. SUMMARY: Calcium imaging and direct measurement of calcium currents demonstrate that primary cilia are sensory organelles that house several types of functional calcium channels. Although intracellular calcium now allows a functional readout for primary cilia, discussions on the relative contributions of the several channel types have just begun. Perhaps, all of these calcium channels are required and necessary to differentiate stimuli in different microenvironments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.