ArticlePLoS neglected tropical diseases2016
Relative Contribution of Dengue IgG Antibodies Acquired during Gestation or Breastfeeding in Mediating Dengue Disease Enhancement and Protection in Type I Interferon Receptor-Deficient Mice.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Conserved pathogenesis of ancestral and contemporary Oropouche virus strains in a murine pregnancy model.Nature communications · 2026Article
- Comparative analysis of placental transmission mechanisms for Dengue and Zika viruses: outcomes and future directions.Frontiers in immunology · 2026Review
- Detection of Dengue Virus RNA in Breast Milk Following Peripartum Infection - Guangzhou City, Guangdong Province, China, 2024.China CDC weekly · 2025Article
- Age-specific kinetics of neutralizing antibodies and infection enhancement among ≤1 year-old Indian infants.Frontiers in cellular and infection microbiology · 2025Article
- DIC-like syndrome in a post-pre-eclampsia birth in a premature infant in a peri-COVID scenario.Case reports in perinatal medicine · 2023Article
- Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development.Vaccines · 2021Review
- Revisiting Koch's postulate to determine the plausibility of viral transmission by human milk.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Article
- Article
- A murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice.Animal models and experimental medicine · 2021Article
- Changes in complement alternative pathway components, factor B and factor H during dengue virus infection in the AG129 mouse.The Journal of general virology · 2021Article
- Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice.Science translational medicine · 2020Article
- Adaptive immune responses to primary and secondary dengue virus infections.Nature reviews. Immunology · 2019Review
- Seroprevalence of Dengue Virus and Rickettsial Infections in Cambodian Children.The American journal of tropical medicine and hygiene · 2019Article
- Seroepidemiology of Dengue, Zika, and Yellow Fever Viruses among Children in the Democratic Republic of the Congo.The American journal of tropical medicine and hygiene · 2018Article
- Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants.Parasites & vectors · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus (DENV) causes a spectrum of diseases ranging from self-limiting dengue fever to severe conditions such as haemorrhagic fever and dengue shock syndrome. Antibody-dependent enhancement (ADE) is thought to explain the occurrence of severe dengue whereby pre-existing binding but non-neutralising antibodies enhance DENV infection. The ADE phenomenon is supported by epidemiological findings that infants that born to dengue immune mothers are at greater risk to develop severe dengue upon primary infection. The role of maternally acquired dengue-specific antibodies in disease enhancement was recently recapitulated in a mouse model where mice born to DENV1-immune mothers experienced enhanced disease severity upon DENV2 infection. Here, this study investigates the relative contribution of maternal dengue-specific antibodies acquired during gestation and breastfeeding in dengue disease. Using a surrogate breastfeeding mother experimental approach, we showed that majority of the maternal dengue-specific antibodies were acquired during breastfeeding and conferred an extended enhancement window. On the other hand, in the context of homologous infection, breastfeeding conferred protection. Furthermore, measurement of dengue-specific antibody titres over time in mice born to dengue immune mothers revealed a biphasic pattern of antibody decay as reported in humans. Our work provides evidence of the potential contribution of breast milk-acquired dengue-specific IgG antibodies in enhancement and protection against dengue. Should such contribution be established in humans as well, it may have important implications for the development of guidelines to dengue-immune breastfeeding mothers.
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