ArticleJournal of the mechanical behavior of biomedical materials2016
Characterization of the viscoelastic behavior of a simplified collagen micro-fibril based on molecular dynamics simulations.
Article in Journal of the mechanical behavior of biomedical materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 24 citations in OpenAlex.
- A coarse-grained molecular dynamics investigation of the role of mineral arrangement on the mechanical properties of mineralized collagen fibrils.Journal of the Royal Society, Interface · 2023Article
- Exploring the Mechanical Properties and Performance of Type-I Collagen at Various Length Scales: A Progress Report.Materials (Basel, Switzerland) · 2022Review
- Strain rate induced toughening of individual collagen fibrils.Applied physics letters · 2022Article
- Appropriate Tensile Mode and Timing of Applying Tension to Promote Tendon Gel Regeneration.Tissue engineering and regenerative medicine · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Collagen fibril is a major component of connective tissues such as bone, tendon, blood vessels, and skin. The mechanical properties of this highly hierarchical structure are greatly influenced by the presence of covalent cross-links between individual collagen molecules. This study investigates the viscoelastic behavior of a collagen lysine-lysine cross-link based on creep simulations with applied forces in the range or 10 to 2000pN using steered molecular dynamics (SMD). The viscoelastic model of the cross-link was combined with a system composed by two segments of adjacent collagen molecules hence representing a reduced viscoelastic model for a simplified micro-fibril. It was found that the collagen micro-fibril assembly had a steady-state Young׳s modulus ranging from 2.24 to 3.27GPa, which is in agreement with reported experimental measurements. The propagation of longitudinal force wave along the molecule was implemented by adding a delay element to the model. The force wave speed was found to be correlated with the speed of one-dimensional elastic waves in rods. The presented reduced model with three degrees of freedom can serve as a building block for developing models of the next level of hierarchy, i.e., a collagen fibril.
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Registered trials
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