ArticleComparative biochemistry and physiology. Part D, Genomics & proteomics2016
Identification of putative circadian clock genes in the American horseshoe crab, Limulus polyphemus.
Article in Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Mitochondrial DNA sequence of the horseshoe crabMitochondrial DNA. Part B, Resources · 2021Article
- Draft genomic and transcriptome resources for marine chelicerate Tachypleus tridentatus.Scientific data · 2019Article
- Article
- Sequences of Circadian Clock Proteins in the Nudibranch Molluscs Hermissenda crassicornis, Melibe leonina, and Tritonia diomedea.The Biological bulletin · 2018Article
- Functional characterization of the circadian clock in the Antarctic krill, Euphausia superba.Scientific reports · 2017Article
- The Draft Genome and Transcriptome of the Atlantic Horseshoe Crab,International journal of genomics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
While the American horseshoe crab, Limulus polyphemus, has robust circadian and circatidal rhythms, virtually nothing is known about the molecular basis of these rhythms in this species or any other chelicerate. In this study, next generation sequencing was used to assemble transcriptomic reads and then putative homologs of known core and accessory circadian genes were identified in these databases. Homologous transcripts were discovered for one circadian clock input gene, five core genes, 22 accessory genes, and two possible output pathways. Alignments and functional domain analyses showed generally high conservation between the putative L. polyphemus clock genes and homologs from Drosophila melanogaster and Daphnia pulex. The presence of both cry1 and cry2 in the L. polyphemus transcriptome would classify its system as an "ancestral", type 2 clock system. In addition, a novel duplication of CYCLE, and a novel triplication of PERIOD were found. Investigations are currently underway to determine if any of these "circadian" genes also participate in the molecular processes that drive the Limulus circatidal clock.
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Registered trials
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