ArticleOncotarget2016
Molecular characteristics of circulating tumor cells resemble the liver metastasis more closely than the primary tumor in metastatic colorectal cancer.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Longitudinal Analysis of Manually and Automatically Classified Circulating Tumor Biomarkers and their Prediction of Survival in Metastatic Colorectal Cancer.Clinical pharmacology and therapeutics · 2026Article
- Epigenetic modulation of CTCs as a novel therapeutic target in oncology.Molecular and cellular biochemistry · 2026Review
- Genetic background and oncogenic driver determines the genomic evolution and transcriptomics of mammary tumor metastasis.Communications biology · 2025Article
- Circulating tumor cells: from new biological insights to clinical practice.Signal transduction and targeted therapy · 2024Review
- Liquid Biopsies in Colorectal Liver Metastases: Towards the Era of Precision Oncologic Surgery.Cancers · 2022Review
- An Immunological Perspective of Circulating Tumor Cells as Diagnostic Biomarkers and Therapeutic Targets.Life (Basel, Switzerland) · 2022Review
- Expression of Prostate Specific Membrane Antigen (PSMA) in Breast Cancer.Geburtshilfe und Frauenheilkunde · 2022Article
- Consensus molecular subtypes of primary colon tumors and their hepatic metastases.Future science OA · 2021Article
- Prognostic and immunological roles of Fc fragment of IgG binding protein in colorectal cancer.Oncology letters · 2021Article
- FCGBP Is a Prognostic Biomarker and Associated With Immune Infiltration in Glioma.Frontiers in oncology · 2021Article
- Prospective Evaluation of a Circulating Tumor Cell Sensitivity Profile to Predict Response to Cisplatin Chemotherapy in Metastatic Breast Cancer Patients.Frontiers in oncology · 2021Article
- IgG Fc Binding Protein (OncoTargets and therapy · 2021Article
- Evaluation of the Role of Circulating Tumor Cells and Microsatellite Instability Status in Predicting Outcome of Advanced CRC Patients.Journal of personalized medicine · 2020Article
- Genetic Heterogeneity of Single Circulating Tumour Cells in Colorectal Carcinoma.International journal of molecular sciences · 2020Article
- HER2 expression on tumor-derived extracellular vesicles and circulating tumor cells in metastatic breast cancer.Breast cancer research : BCR · 2020Article
- Histopathological growth patterns and positive margins after resection of colorectal liver metastases.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2020Article
- Tumour-derived extracellular vesicles in blood of metastatic cancer patients associate with overall survival.British journal of cancer · 2020Article
- Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer.Genome medicine · 2020Article
- Circulating Tumor Cells Expressing the Prostate Specific Membrane Antigen (PSMA) Indicate Worse Outcome in Primary, Non-Metastatic Triple-Negative Breast Cancer.Frontiers in oncology · 2020Article
- Liquid Biopsy as a Tool Exploring in Real-Time Both Genomic Perturbation and Resistance to EGFR Antagonists in Colorectal Cancer.Frontiers in oncology · 2020Review
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCTCs are a promising alternative for metastatic tissue biopsies for use in precision medicine approaches. We investigated to what extent the molecular characteristics of circulating tumor cells (CTCs) resemble the liver metastasis and/or the primary tumor from patients with metastatic colorectal cancer (mCRC).
resultsThe CTC profiles were concordant with the liver metastasis in 17/23 patients (74%) and with the primary tumor in 13 patients (57%). The CTCs better resembled the liver metastasis in 13 patients (57%), and the primary tumor in five patients (22%). The strength of the correlations was not associated with clinical parameters. Nine genes (CDH1, CDH17, CDX1, CEACAM5, FABP1, FCGBP, IGFBP3, IGFBP4, and MAPT) displayed significant differential expressions, all of which were downregulated, in CTCs compared to the tissues in the 23 patients. PATIENTS AND
methodsPatients were retrospectively selected from a prospective study. Using the CellSearch System, CTCs were enumerated and isolated just prior to liver metastasectomy. A panel of 25 CTC-specific genes was measured by RT-qPCR in matching CTCs, primary tumors, and liver metastases. Spearman correlation coefficients were calculated and considered as continuous variables with r=1 representing absolute concordance and r=-1 representing absolute discordance. A cut-off of r>0.1 was applied in order to consider profiles to be concordant.
conclusionsIn the majority of the patients, CTCs reflected the molecular characteristics of metastatic cells better than the primary tumors. Genes involved in cell adhesion and epithelial-to-mesenchymal transition were downregulated in the CTCs. Our results support the use of CTC characterization as a liquid biopsy for precision medicine.
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