ReviewWiley interdisciplinary reviews. Systems biology and medicine2016
Systems physiology of the airways in health and obstructive pulmonary disease.
Review in Wiley interdisciplinary reviews. Systems biology and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Impaired lung deformation during expiration in chronic obstructive pulmonary disease using four-dimensional dynamic-ventilation CT.Quantitative imaging in medicine and surgery · 2026Article
- The testosterone paradox in asthma.Frontiers in allergy · 2026Review
- The Effect of Aerobic Training on Healthy Small Airways-A Forced Oscillation Technique Approach to Optimize Long Term Care in COPD.Journal of clinical medicine · 2025Article
- In utero exposure to experimental maternal asthma alters fetal airway development in sheep.Experimental physiology · 2025Article
- AutoCOPD-A novel and practical machine learning model for COPD detection using whole-lung inspiratory quantitative CT measurements: a retrospective, multicenter study.EClinicalMedicine · 2025Article
- Work of Breathing for Aviators: A Missing Link in Human Performance.Life (Basel, Switzerland) · 2024Article
- Modeling Realistic Geometries in Human Intrathoracic Airways.Diagnostics (Basel, Switzerland) · 2024Review
- Systems Engineering Approach to Modeling and Analysis of Chronic Obstructive Pulmonary Disease Part II: Extension for Variable Metabolic Rates.ACS omega · 2024Article
- Respiratory Oscillometry and Functional Performance in Different COPD Phenotypes.International journal of chronic obstructive pulmonary disease · 2024Article
- More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?Experimental physiology · 2023Article
- Systems Engineering Approach to Modeling and Analysis of Chronic Obstructive Pulmonary Disease.ACS omega · 2023Article
- Wireless Communication Platform Based on an Embroidered Antenna-Sensor for Real-Time Breathing Detection.Sensors (Basel, Switzerland) · 2022Article
- Strain Analysis in Patients at High-Risk for COPD Using Four-Dimensional Dynamic-Ventilation CT.International journal of chronic obstructive pulmonary disease · 2022Article
- Soft robotic constrictor for in vitro modeling of dynamic tissue compression.Scientific reports · 2021Article
- The lower respiratory airway wall in children in health and disease.ERJ open research · 2021Review
- Dynamic airway function during exercise in COPD assessed via impulse oscillometry before and after inhaled bronchodilators.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Go with the flow-clinical importance of flow curves during mechanical ventilation: A narrative review.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2020Article
- Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung.Alcohol (Fayetteville, N.Y.) · 2019Article
- New insights in respiratory impedance in young children after repair of congenital diaphragmatic hernia: a cross-sectional study.Italian journal of pediatrics · 2019Article
- Correlation between the severity of asthma and computed tomography-based large airway structural changes among children under 3 years of age.Annals of thoracic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Fresh air entering the mouth and nose is brought to the blood-gas barrier in the lungs by a repetitively branching network of airways. Provided the individual airway branches remain patent, this airway tree achieves an enormous amplification in cross-sectional area from the trachea to the terminal bronchioles. Obstructive lung diseases such as asthma occur when airway patency becomes compromised. Understanding the pathophysiology of these obstructive diseases thus begins with a consideration of the factors that determine the caliber of an individual airway, which include the force balance between the inward elastic recoil of the airway wall, the outward tethering forces of its parenchymal attachments, and any additional forces due to contraction of airway smooth muscle. Other factors may also contribute significantly to airway narrowing, such as thickening of the airway wall and accumulation of secretions in the lumen. Airway obstruction becomes particularly severe when these various factors occur in concert. However, the effect of airway abnormalities on lung function cannot be fully understood only in terms of what happens to a single airway because narrowing throughout the airway tree is invariably heterogeneous and interdependent. Obstructive lung pathologies thus manifest as emergent phenomena arising from the way in which the airway tree behaves a system. These emergent phenomena are studied with clinical measurements of lung function made by spirometry and by mechanical impedance measured with the forced oscillation technique. Anatomically based computational models are linking these measurements to underlying anatomic structure in systems physiology terms. WIREs Syst Biol Med 2016, 8:423-437. doi: 10.1002/wsbm.1347 For further resources related to this article, please visit the WIREs website.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.