ArticleCritical care medicine2016
Reciprocal Risk of Acute Kidney Injury and Acute Respiratory Distress Syndrome in Critically Ill Burn Patients.
Article in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence and Mortality of Acute Respiratory Distress Syndrome in Patients With Burns: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- The prevalence, risk factors, and in-hospital mortality of acute kidney injury according to KDIGO criteria in burn patients.Renal failure · 2025Article
- Early Acute Kidney Injury in Adult Burn Patients: Outcome and Risk Factors.Annals of burns and fire disasters · 2025Article
- Acute kidney injury in patients with burns.Nature reviews. Nephrology · 2024Review
- Temporal Relationship and Clinical Outcomes of Acute Kidney Injury Following Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis.Critical care explorations · 2024Review
- Incidence, Outcomes, and Predictors of Subphenotypes of Acute Kidney Injury among Acute Respiratory Distress Syndrome Patients: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Review
- Machine learning for early discrimination between transient and persistent acute kidney injury in critically ill patients with sepsis.Scientific reports · 2021Article
- Acute kidney injury in acute respiratory distress syndrome: why ventilator settings matter.Annals of translational medicine · 2020Article
- Outcomes among Patients Treated with Renal Replacement Therapy during Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Study.Blood purification · 2020Article
- Factors associated with acute kidney injury in acute respiratory distress syndrome.Annals of intensive care · 2019Article
- Factors associated with acute kidney injury in the Helsinki Burn Centre in 2006-2015.Scandinavian journal of trauma, resuscitation and emergency medicine · 2018Article
- Understanding the kidney during acute respiratory failure.Intensive care medicine · 2017Review
- Unusual Relationship: Do Organs Talk to Each Other?Critical care medicine · 2016Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the association between acute respiratory distress syndrome and acute kidney injury with respect to their contributions to mortality in critically ill patients.
designRetrospective analysis of consecutive adult burn patients requiring mechanical ventilation.
settingA 16-bed burn ICU at tertiary military teaching hospital. PATIENTS: Adult patients more than 18 years old requiring mechanical ventilation during their initial admission to our burn ICU from January 1, 2003, to December 31, 2011.
interventionsNone. MEASUREMENTS AND MAIN
resultsA total 830 patients were included, of whom 48.2% had acute kidney injury (n = 400). These patients had a 73% increased risk of developing acute respiratory distress syndrome after controlling for age, gender, total body surface area burned, and inhalation injury (hazard ratio, 1.73; 95% CI, 1.18-2.54; p = 0.005). In a reciprocal multivariate analysis, acute respiratory distress syndrome (n = 299; 36%) demonstrated a strong trend toward developing acute kidney injury (hazard ratio, 1.39; 95% CI, 0.99-1.95; p = 0.05). There was a 24% overall in-hospital mortality (n = 198). After adjusting for the aforementioned confounders, both acute kidney injury (hazard ratio, 3.73; 95% CI, 2.39-5.82; p < 0.001) and acute respiratory distress syndrome (hazard ratio, 2.16; 95% CI, 1.58-2.94; p < 0.001) significantly contributed to mortality. Age, total body surface area burned, and inhalation injury were also significantly associated with increased mortality.
conclusionsAcute kidney injury increases the risk of acute respiratory distress syndrome in mechanically ventilated burn patients, whereas acute respiratory distress syndrome similarly demonstrates a strong trend toward the development of acute kidney injury. Acute kidney injury and acute respiratory distress syndrome are both independent risks for subsequent death. Future research should look at this interplay for possible early interventions.
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