Evidence map›Paper›PMID 27340670›Full record

ArticleBioMed research international2016

Therapeutic Effects of CUR-Activated Human Umbilical Cord Mesenchymal Stem Cells on 1-Methyl-4-phenylpyridine-Induced Parkinson's Disease Cell Model.

Li Jinfeng, Wang Yunliang, Liu Xinshan, Wang Yutong, Wang Shanshan, Xue Peng, Yang Xiaopeng, Xu Zhixiu, Lu Qingshan, Yin Honglei and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Mesenchymal Stem Cells for Neurological Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Li JinfengNeurology Department of General Hospital of Jinan Military Region, Jinan, Shandong 250031, China.
Wang YunliangThe Neurology Department, The 148th Hospital, Zibo, Shandong 255300, China.
Liu XinshanSanbo Brain Hospital Capital Medical University, Haidian District, Beijing 100093, China.
Wang YutongMedical School of Henan University, Zhengzhou, Henan 475000, China.
Wang ShanshanThe Neurology Department, The 148th Hospital, Zibo, Shandong 255300, China.
Xue PengNeurology Department, The Second Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450014, China.
Yang XiaopengNeurology Department, The Second Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450014, China.
Xu ZhixiuNeurology Department, The Second Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450014, China.
Lu QingshanNeurology Department, The Second Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450014, China.
Yin HongleiThe Neurology Department, The 148th Hospital, Zibo, Shandong 255300, China.
Cao XiaNeurology Department of General Hospital of Jinan Military Region, Jinan, Shandong 250031, China.
Wang HongweiDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Cao BingzhenNeurology Department of General Hospital of Jinan Military Region, Jinan, Shandong 250031, China.
Second Affiliated Hospital of Zhengzhou University · CNJinan Military General Hospital · CNBeijing Sanbo Brain Hospital · CNHenan University · CNUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study is to evaluate the therapeutic effects of human umbilical cord-derived mesenchymal stem cells (hUC-MSC) activated by curcumin (CUR) on PC12 cells induced by 1-methyl-4-phenylpyridinium ion (MPP+), a cell model of Parkinson's disease (PD). The supernatant of hUC-MSC and hUC-MSC activated by 5 µmol/L CUR (hUC-MSC-CUR) were collected in accordance with the same concentration. The cell proliferation and differentiation potential to dopaminergic neuronal cells and antioxidation were observed in PC12 cells after being treated with the above two supernatants and 5 µmol/L CUR. The results showed that the hUC-MSC-CUR could more obviously promote the proliferation and the expression of tyrosine hydroxylase (TH) and microtubule associated protein-2 (MAP2) and significantly decreased the expression of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in PC12 cells. Furtherly, cytokines detection gave a clue that the expression of IL-6, IL-10, and NGF was significantly higher in the group treated with the hUC-MSC-CUR compared to those of other two groups. Therefore, the hUC-MSC-CUR may be a potential strategy to promote the proliferation and differentiation of PD cell model, therefore providing new insights into a novel therapeutic approach in PD.

Indexed as

Mesenchymal Stem Cell TransplantationModels, Biological1-Methyl-4-phenylpyridiniumAnimalsApoptosisCaspasesCell DifferentiationCell ProliferationCell SeparationCurcuminCytokinesDopamineDopamine Plasma Membrane Transport ProteinsHumansMesenchymal Stem CellsNeurons1-Methyl-4-phenylpyridiniumCaspasesCurcuminCytokinesDopamineDopamine Plasma Membrane Transport ProteinsNitric OxideNitric Oxide Synthase Type IIProto-Oncogene Proteins c-bcl-2Tyrosine 3-Monooxygenase

Identifiers

PMID27340670
PMCPMC4906196
OpenAlexW2414567852

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.