Evidence map›Paper›PMID 27340011›Full record

ArticleThe Libyan journal of medicine2016

Effect of IL-1β and IL-1RN polymorphisms in carcinogenesis of the gastric mucosa in patients infected with Helicobacter pylori in Algeria.

Amine El-Mokhtar Drici, Soraya Moulessehoul, Abdelkarim Tifrit, Mustapha Diaf, Douidi Kara Turki, Meryem Bachir, Abdenacer Tou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Libyan journal of medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Amine El-Mokhtar DriciDepartment of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University, Sidi-Bel-Abbes, Algeria; drici.amine@gmail.com.
Soraya MoulessehoulDepartment of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University, Sidi-Bel-Abbes, Algeria.
Abdelkarim TifritDepartment of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University, Sidi-Bel-Abbes, Algeria.
Mustapha DiafDepartment of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University, Sidi-Bel-Abbes, Algeria.
Douidi Kara TurkiDepartment of Gastroenterology, University Hospital of Sidi-Bel-Abbes, Sidi-Bel-Abbes, Algeria.
Meryem BachirDepartment of Biology, Faculty of Sciences, Hassiba Ben Bouali University, Chlef, Algeria.
Abdenacer TouAnatomopathology Department, University Hospital of Sidi-Bel-Abbes, Sidi-Bel-Abbes, Algeria.
Université Djilali de Sidi Bel Abbès · DZHassiba Benbouali University of Chlef · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfection with Helicobacter pylori is considered a potential risk of developing gastric cancer in association with contributing host genetic factor. IL-1β and IL-1RN polymorphisms appear to maintain and promote Helicobacter pylori infection and to stimulate neoplastic growth of the gastric mucosa. OBJECTIVE AND

methodsIn order to elucidate the effect of these polymorphisms in combination with gastric cancer in a population from northwestern Algeria, a case-control study was carried out on 79 patients infected with H. pylori with chronic atrophic gastritis and/or gastric carcinoma, and 32 subjects were recruited as case-control. IL-1β-31 bi-allelic and IL-1β-511 bi-allelic polymorphisms and IL-1RN penta-allelic were genotyped.

resultsIL-1β-31C was associated with an increased risk of developing gastric carcinoma (OR=4.614 [1.43-14.81], p=0.01). However, IL-1RN2 heterozygous allele type was significantly associated with chronic atrophic gastritis (OR=4.2 [1.23-3.61], p=0.022). IL-1β-511T was associated with an increased risk of development of chronic atrophic gastritis (OR=4.286 [1.54-11.89], p=0.005).

conclusionIL-1β and IL-1RN polymorphisms associated with H. pylori infection contribute to the development of chronic atrophic gastritis and gastric carcinomas in an Algerian population. The alleles IL-1β-31C and IL-1RN were associated with an increased risk of developing gastric carcinoma, and IL-1β-511T with an increased risk of developing chronic atrophic gastritis with no significant association of developing gastric carcinoma.

Indexed as

AdolescentAdultAgedAged, 80 and overAlgeriaCase-Control StudiesFemaleGastric MucosaGenetic Predisposition to DiseaseHelicobacter pyloriHumansInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinMaleMiddle AgedPolymorphism, Single NucleotideIL1B protein, humanIL1RN protein, humanInterleukin-1betaInterleukin 1 Receptor Antagonist Proteingastric mucosaHelicobacter pyloriIL-1RNIL-1β

Identifiers

PMID27340011
PMCPMC4919366
OpenAlexW2468408187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.