Evidence map›Paper›PMID 27339806›Full record

Trial reportThe journal of headache and pain2016

The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients.

Saras Menon, Bushra Nasir, Nesli Avgan, Sussan Ghassabian, Christopher Oliver, Rodney Lea, Maree Smith, Lyn Griffiths

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review on Headache Related to Dietary Supplements.Current pain and headache reports · 2022
    Review
  9. Review
  10. Migraine and Diet.Nutrients · 2020
    Review
  11. Review
  12. Review
  13. The association between serum vitamin BNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Saras MenonGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Bushra NasirGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Nesli AvganGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Sussan GhassabianCentre for Integrated Preclinical Drug Development Faculty of Medicine and Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.
Christopher OliverBlackmores Institute, 20 Jubilee Avenue, Warriewood, NSW 2102, Australia.
Rodney LeaGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Maree SmithCentre for Integrated Preclinical Drug Development Faculty of Medicine and Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.
Lyn GriffithsGenomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia. lyn.griffiths@qut.edu.au.ORCID http://orcid.org/0000-0002-6774-5475
Queensland University of Technology · AUThe University of Queensland · AUBlack Dog Institute · AUGriffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMigraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurrence of migraine in women. The current study examined the occurrence of migraine in response to vitamin supplementation with a lower dose of folic acid.

methodsThis was a 6 month randomised, double blinded placebo controlled trial of daily vitamin supplementation containing 1 mg of folic acid, 25 mg of Vitamin B6 and Vitamin B12, on reduction of homocysteine and the occurrence of migraine in 300 female patients diagnosed with migraine with aura.

resultsVitamin supplementation with 1 mg of folic acid, did not significantly decrease homocysteine levels (P = 0.2). The treatment group did not show a significant decrease in the percentage of participants with high migraine disability, severity or frequency at the end of the 6 month intervention (P > 0.1).

conclusion1 mg of folic acid in combination with vitamin B6 and B12 is less effective in reducing migraine associated symptoms compared to the previously tested dosage of 2 mg folic acid in combination with 25 mg of vitamin B6 and 400 μg of vitamin B12.

Indexed as

Dietary SupplementsAdolescentAdultDouble-Blind MethodDrug Therapy, CombinationFemaleFolic AcidFollow-Up StudiesHumansMiddle AgedMigraine with AuraTreatment OutcomeVitamin B 12Vitamin B 6Young AdultFolic AcidVitamin B 12Vitamin B 6FolateFolic acidMigraineVitamin B12Vitamin B6

Identifiers

PMID27339806
PMCPMC4919187
OpenAlexW2466302541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.