Evidence map›Paper›PMID 27339670›Full record

ReviewCalcified tissue international2017

Restrictive Eating Disorders and Skeletal Health in Adolescent Girls and Young Women.

Darcey Thornton, Catherine M Gordon

Registry-linked trialAbstract readReview
In one paragraph

Review in Calcified tissue international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04508088 (Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04508088 recruitingnot on this mapstarted 2020, after this paper: background citation

Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease

TypeobservationalSponsorMassachusetts General HospitalRan2020 to 2026Enrolled92ConditionsInflammatory Bowel Disease, Crohn DiseaseArmsCoronal T1 weighted spin echo images, Spin-lattice relaxation (T1), Magnetic resonance spectroscopy, Blood Draw
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Lonafarnib clinical trials demonstrate uncoupling of the muscle-bone unit in Hutchinson-Gilford Progeria Syndrome.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Oral contraceptive use and fracture risk-a retrospective study of 12,970 women in the UK.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Darcey ThorntonDivision of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave MLC 4000, Cincinnati, OH, 45229, USA.
Catherine M GordonDivision of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave MLC 4000, Cincinnati, OH, 45229, USA. catherine.gordon@cchmc.org.

Funding

Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMDR01AR060829 · NIAMS · RHODE ISLAND HOSPITAL · PI GORDON, CATHERINE M. · 2011 to 2015
$1.4M
NIAMS NIH HHS R01 AR060829
6 · The paper itself

Abstract

This article reviews the effects of restrictive eating disorders on bone health. The relationship between eating disorders and amenorrhea is discussed in detail. The pathologic impact of malnutrition on bone is explored by examining the results of studies using various available imaging techniques. The multiple hormonal alterations seen in adolescents and young women with anorexia nervosa are reviewed, as well as how these alterations may influence bone turnover, density, structure, and strength. The diagnostic clinical evaluation for adolescents and young women with these disorders is also outlined. Available treatment options, including those that hold promise for efficacy, as well as those we deemed to be ineffective, are considered from both the clinical and mechanistic standpoints. Finally, future research opportunities are offered, including intriguing work in the area of fat and bone interactions.

Indexed as

AdolescentAdultAmenorrheaBone and BonesFeeding and Eating DisordersFemaleHumansYoung AdultAmenorrheaAnorexia nervosaEating disorderLow bone mineral densityOsteoporosis

Identifiers

PMID27339670
PMCPMC9767748

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.