Evidence map›Paper›PMID 27339627›Full record

ArticleFEBS letters2016

Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr(-/-) mice.

Paulette A Krishack, Timothy J Sontag, Godfrey S Getz, Catherine A Reardon

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Paulette A KrishackMolecular Pathogenesis and Molecular Medicine Graduate Program, University of Chicago, IL, USA.
Timothy J SontagDepartment of Pathology, University of Chicago, IL, USA.
Godfrey S GetzMolecular Pathogenesis and Molecular Medicine Graduate Program, University of Chicago, IL, USA.
Catherine A ReardonMolecular Pathogenesis and Molecular Medicine Graduate Program, University of Chicago, IL, USA.
Molecular Biology Consortium · USUniversity of Chicago · USUniversity of Illinois Chicago · US

Funding

Role of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 2008 to 2019
$23.5M
CARDIOVASCULAR PATHOPHYSIOLOGY &BIOCHEMISTRY TRAININGT32HL007237 · NHLBI · UNIVERSITY OF CHICAGO · PI GETZ, GODFREY SHALOM · 1985 to 2011
$5.0M
NHLBI NIH HHS P01 HL092969NHLBI NIH HHS T32 HL007237
6 · The paper itself

Abstract

We previously showed that feeding a Western-type diet (WTD) to Ldlr(-/-) mice lacking serum amyloid A (SAA) (Saa(-/-) Ldlr(-/-) mice), the level of total blood monocytes was higher than in Ldlr(-/-) mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage-dendritic cell progenitor (MDP) cells were found in WTD-fed Saa(-/-) Ldlr(-/-) mice compared to Ldlr(-/-) mice and lower levels of GMP cells and CMP cells in Ldlr(-/-) mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice.

Indexed as

AnimalsAtherosclerosisBone MarrowBone Marrow TransplantationDendritic CellsDisease Models, AnimalHumansHyperlipoproteinemiasMacrophagesMiceMice, KnockoutMonocytesMyeloid CellsReceptors, LDLSerum Amyloid A ProteinReceptors, LDLSerum Amyloid A Proteinmonocytesmonopoiesisserum amyloid Astem cellsWestern-type diet

Identifiers

PMID27339627
PMCPMC4992419
OpenAlexW2463490117

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.