Evidence map›Paper›PMID 27339606›Full record

Observational studyInternational journal of obesity (2005)2016

Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C.

T Ruiz-Lozano, J Vidal, A de Hollanda, M Canteras, M Garaulet, M Izquierdo-Pulido

Abstract readObservational Study
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In one paragraph

Observational study in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

T Ruiz-LozanoDepartment Food Science and Nutrition, University of Barcelona, Barcelona, Spain.
J VidalObesity Unit, Endocrinology and Nutrition Department, Hospital Clinic Universitari, Barcelona, Spain.
A de HollandaObesity Unit, Endocrinology and Nutrition Department, Hospital Clinic Universitari, Barcelona, Spain.
M CanterasDepartment of Biostatistics, University of Murcia, Murcia, Spain.
M GarauletDepartment of Physiology, Faculty of Biology, University of Murcia, Murcia. Spain.
M Izquierdo-PulidoDepartment Food Science and Nutrition, University of Barcelona, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronotype has been related to obesity and metabolic disturbances. However, little is known about the relationship between circadian preferences and genetic background in CLOCK genes with obesity and weight loss among severely obese patients after bariatric surgery.

objectivesThe research goals were (1) to examine whether evening chronotype is related to obesity and weight loss evolution in severely obese followed during 6 years after bariatric surgery and (2) to examine potential interactions between circadian preferences and CLOCK 3111T/C for obesity in this population. SUBJECTS/

methodsParticipants (n=252, 79% female; age (mean±s.d.): 52±11 years; body mass index (BMI): 46.4±6.0 kg m

resultsEvening-type subjects showed significantly higher initial body weight (P=0.015) and BMI (P=0.014) than morning types. Moreover, evening-type, when compared with morning types, lost less weight (percentage of excess weight loss) after bariatric surgery (P=0.015). Weight-loss progression between the two chronotype groups differed significantly from the fourth year after the bariatric surgery toward a higher weight regain among evening types (P<0.05). We also detected a significant interaction between CLOCK 3111T/C SNP and chronotype for body weight at baseline (P<0.001). Specifically, among carriers of the risk allele C, evening types showed higher body weight than morning types (P=0.012). In addition, CLOCK 3111T/C SNP significantly associated with obesity and sleep duration in the older subjects.

conclusionsEvening chronotype is associated with higher obesity in severely obese subjects and with lower weight loss effectiveness after bariatric surgery. In addition, circadian preferences interact with CLOCK 3111T/C for obesity. The circadian and genetic assessment could provide tailored weight loss recommendations in subjects who underwent bariatric surgery.

Indexed as

Circadian RhythmAdultBariatric SurgeryCLOCK ProteinsEnergy MetabolismFeeding BehaviorFemaleFollow-Up StudiesGene FrequencyGenetic VariationGenotypeHumansMaleMiddle AgedObesity, MorbidProspective StudiesCLOCK protein, humanCLOCK Proteins

Identifiers

PMID27339606

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.