ArticleInternational journal of obesity (2005)2016
Long-term glucocorticoid concentrations as a risk factor for childhood obesity and adverse body-fat distribution.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Associations Between Different Cortisol Measures and Adiposity in Children: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?Frontiers in neuroendocrinology · 2020Pooled it
- Longitudinal Examination of Hair Cortisol Concentrations and Weight Changes in Preschool-Aged Children of Latino Farmworkers.Childhood obesity (Print) · 2023Trial
- Trial
- Trial
- Adipocyte-specific MC2R overexpression exerts minimal metabolic effects in mice.Laboratory animal research · 2026Article
- Does cortisol mediate the association between school bullying and weight status in preadolescents?European child & adolescent psychiatry · 2026Article
- Lower Cortisol and Dehydroepiandrosterone Sulfate and Higher Food Addiction in Childhood Obesity: Associations With Stress and Dietary Parameters.Journal of the Endocrine Society · 2025Article
- Sex-specific associations between body composition and depression among U.S. adults: a cross-sectional study.Lipids in health and disease · 2025Article
- Cortisol/Cortisone Ratio in Youth with Obesity One Year Following Sleeve Gastrectomy.Metabolic syndrome and related disorders · 2024Article
- Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGF-β.JCI insight · 2024Article
- Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts.Nutrients · 2024Review
- Dietary habits, depression and obesity: an intricate relationship to explore in pediatric preventive strategies.Frontiers in pediatrics · 2024Review
- Adipocyte Glucocorticoid Receptor Inhibits Immune Regulatory Genes to Maintain Immune Cell Homeostasis in Adipose Tissue.Endocrinology · 2023Article
- Systematic metabolomic studies identified adult adiposity biomarkers with acetylglycine associated with fat lossFrontiers in molecular biosciences · 2023Article
- Role of glucocorticoid metabolism in childhood obesity-associated hypertension.Endocrine connections · 2022Article
- Difference in Hair Cortisol Concentrations between Obese and Non-Obese Children and Adolescents: A Systematic Review.Children (Basel, Switzerland) · 2022Review
- Variation in glucocorticoid sensitivity and the relation with obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- The Role of Very Low Calorie Ketogenic Diet in Sympathetic Activation through Cortisol Secretion in Male Obese Population.Journal of clinical medicine · 2021Article
- Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood.The Journal of clinical endocrinology and metabolism · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildhood obesity is an important risk factor for premature development of the metabolic syndrome (MetS) at adulthood. There is need for understanding of the mechanisms underlying the MetS and obesity. Patients with Cushing's disease suffer from similar metabolic complications, leading to the hypothesis that inter-individual cortisol variation may contribute to the onset of obesity. In addition, glucocorticoid receptor (GR)-gene polymorphisms resulting in differential glucocorticoid (GC) sensitivity, have been associated with an adverse metabolic profile.
aimTo study associations of GC levels in scalp hair, as a marker of long-term systemic GC concentrations, and genetically determined GC sensitivity with obesity and body-fat distribution in children.
methodsWe performed a cross-sectional study of cortisol and cortisone concentrations over a 3-month period, measured by LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometry) in hair of 3019 6-year-old children participating in the Generation R study. Genotyping of GR-gene polymorphisms was performed.
resultsOf all children, 4.3% was obese and 13.4% overweight. Cortisol was significantly associated with risk of obesity (odd ratio (OR): 9.4 (3.3-26.9)) and overweight (OR: 1.4 (1.0-2.0)). Cortisone was associated with risk of obesity (OR: 1.9 (1.0-3.5)). Cortisol and cortisone were significantly positively associated with body mass index, fat mass (FM) index and android/gynecoid FM ratio. GR polymorphisms were not associated with adiposity parameters.
conclusionLong-term cortisol concentrations are strongly associated with an increased risk of childhood obesity and adverse body-fat distribution. Future research may reveal whether these are causal relations and may be a target for therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.