Evidence map›Paper›PMID 27339418›Full record

ArticleArchives of toxicology2017

Formaldehyde induces toxicity in mouse bone marrow and hematopoietic stem/progenitor cells and enhances benzene-induced adverse effects.

Chenxi Wei, Huaxiao Wen, Langyue Yuan, Cliona M McHale, Hui Li, Kun Wang, Junlin Yuan, Xu Yang, Luoping Zhang

Open access · greenAbstract read
In one paragraph

Article in Archives of toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
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  4. Genetic polymorphisms ofMolecular biology research communications · 2026
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  8. Review
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  10. Article
  11. Article
  12. Ameliorative effects of hesperidin andToxicology research · 2021
    Article
  13. Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Combined exposure to formaldehyde and PMEnvironment international · 2020
    Article
  18. Article
  19. Article
  20. Effects of environmental stressors on stem cells.World journal of stem cells · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Chenxi WeiHubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, Hubei, China.
Huaxiao WenHubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, Hubei, China.
Langyue YuanHubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, Hubei, China.
Cliona M McHaleDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, 94720, USA.
Hui LiHubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, Hubei, China.
Kun WangHubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, Hubei, China.
Junlin YuanHubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, Hubei, China.
Xu YangHubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, Hubei, China. yangxu@mail.ccnu.edu.cn.
Luoping ZhangDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, 94720, USA. luoping@berkeley.edu.
Central China Normal University · CNUniversity of California, Berkeley · USNew York University · US

Funding

Biomarkers of Formaldehyde Exposure and ToxicityR01ES017452 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHANG, LUOPING · 2009 to 2010
$743k
NIEHS NIH HHS R01 ES017452
6 · The paper itself

Abstract

Formaldehyde (FA) is a human leukemogen and is hematotoxic in human and mouse. The biological plausibility of FA-induced leukemia is controversial because few studies have reported FA-induced bone marrow (BM) toxicity, and none have reported BM stem/progenitor cell toxicity. We sought to comprehensively examine FA hematoxicity in vivo in mouse peripheral blood, BM, spleen and myeloid progenitors. We included the leukemogen and BM toxicant, benzene (BZ), as a positive control, separately and together with FA as co-exposure occurs frequently. We exposed BALB/c mice to 3 mg/m

Indexed as

AnimalsApoptosisBenzeneBlood Cell CountBone Marrow CellsCaspase 3FormaldehydeHematopoietic Stem CellsIntercellular Signaling Peptides and ProteinsMaleMice, Inbred BALB CReactive Oxygen SpeciesReceptors, Growth FactorSpleenToxicity TestsBenzeneCasp3 protein, mouseCaspase 3FormaldehydeIntercellular Signaling Peptides and ProteinsReactive Oxygen SpeciesReceptors, Growth FactorBenzeneBone marrowFormaldehydeHematotoxicityMyeloid progenitor

Identifiers

PMID27339418
PMCPMC6361627
OpenAlexW2470346749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.