Trial reportThe Journal of allergy and clinical immunology2016
Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze.
Abstract readLetterRandomized Controlled Trial
In one paragraph
Trial report in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Azithromycin for acute bronchiolitis and wheezing episodes in children - a systematic review with meta-analysis.Pediatric research · 2024Pooled it
- Exploring the microbial landscape of the nasopharynx in children: a systematic review of studies using next generation sequencing.Frontiers in microbiomes · 2023Pooled it
- The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials.Drug design, development and therapy · 2018Pooled it
- Post-viral lung diseases: the microbiota as a key player.ERJ open research · 2025Review
- Article
- Article
- Azithromycin to Prevent Recurrent Wheeze Following Severe Respiratory Syncytial Virus Bronchiolitis.NEJM evidence · 2022Article
- The azithromycin to prevent wheezing following severe RSV bronchiolitis-II clinical trial: Rationale, study design, methods, and characteristics of study population.Contemporary clinical trials communications · 2021Article
- Early Microbial-Immune Interactions and Innate Immune Training of the Respiratory System during Health and Disease.Children (Basel, Switzerland) · 2021Review
- Antibiotic Treatments During Infancy, Changes in Nasal Microbiota, and Asthma Development: Population-based Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Rapid Increase of Oral Bacteria in Nasopharyngeal Microbiota After Antibiotic Treatment in Children With Invasive Pneumococcal Disease.Frontiers in cellular and infection microbiology · 2021Article
- Review
- Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology.The Journal of allergy and clinical immunology · 2020Article
- Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing.The Journal of allergy and clinical immunology · 2020Article
- Observational
- Effects of Macrolide Treatment during the Hospitalization of Children with Childhood Wheezing Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2018Article
- Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion.The Journal of experimental medicine · 2018Article
- Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children.Current allergy and asthma reports · 2017Review
- Management of preschool recurrent wheezing and asthma: a phenotype-based approach.Current opinion in allergy and clinical immunology · 2017Review
- Better understanding of childhood asthma, towards primary prevention - are we there yet? Consideration of pertinent literature.F1000Research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Yanjiao ZhouThe Jackson Laboratory for Genomic Medicine, Farmington, Conn.
Leonard B BacharierDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Megan Isaacson-SchmidDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Jack BatyDivision of Biostatistics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Kenneth B SchechtmanDivision of Biostatistics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Geneline SajolDepartment of Internal Medicine, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Kristine WylieDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Gregory A StorchDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Mario CastroDepartment of Internal Medicine, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Avraham BeigelmanDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo. Electronic address: beigelman_a@kids.wustl.edu.
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MWashington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8MAZITHROMYCIN TO PREVENT RECURRENT WHEEZING FOLLOWING SEVERE RSV BRONCHIOLITISR01HL130876 · NHLBI · WASHINGTON UNIVERSITY · PI BACHARIER, LEONARD B, BEIGELMAN, AVRAHAM · 2016 to 2020
$3.7MDeterminants of Asthma Following RSV Bronchiolitis in Early LifeR01HL092486 · NHLBI · WASHINGTON UNIVERSITY · PI BACHARIER, LEONARD B, CASTRO, MARIO · 2009 to 2012
$3.0MGENETIC, BIOLOGIC, &IMMUNOLOGIC DETERMINANTS OF ASTHMAR01HL061895 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 1998 to 2006
$2.6MNCATS NIH HHS KL2 TR000450NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NHLBI NIH HHS R01 HL061895NHLBI NIH HHS R01 HL092486NHLBI NIH HHS R01 HL130876
Abstract
PubMed holds no abstract for this paper.
Indexed as
Anti-Bacterial AgentsAzithromycinBronchiolitis, ViralFemaleHumansInfantInfant, NewbornMaleMicrobiotaMoraxellaRespiratory SoundsRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory SystemAnti-Bacterial AgentsAzithromycin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.