Evidence map›Paper›PMID 27339249›Full record

Trial reportThe Journal of pediatrics2016

Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study.

Muriel Le Bourgeois, Agnès Ferroni, Marianne Leruez-Ville, Emmanuelle Varon, Caroline Thumerelle, François Brémont, Michael J Fayon, Christophe Delacourt, Caroline Ligier, Laurence Watier and 2 more

Open access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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  4. Guidelines: Anaesthesia in the context of COVID-19 pandemic.Anaesthesia, critical care & pain medicine · 2020
    Guideline
  5. Improving pain management in childhood acute otitis media in general practice: a cluster randomised controlled trial of a GP-targeted educational intervention.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Muriel Le BourgeoisDepartment of Pediatric Pulmonology, University Hospital Necker-Enfants Malades, APHP, Paris, France. Electronic address: muriel.lebourgeois@nck.aphp.fr.
Agnès FerroniDepartment of Microbiology, University Hospital Necker-Enfants Malades, APHP, Paris, France.
Marianne Leruez-VilleDepartment of Microbiology, University Hospital Necker-Enfants Malades, APHP, Paris, France.
Emmanuelle VaronDepartment of Microbiology, European Hospital Georges-Pompidou, APHP, Paris, France; National Reference Center for Pneumococci, APHP, Paris, France.
Caroline ThumerelleDepartment of Pediatric Pulmonology, University Hospital Jeanne de Flandre, Université Nord de France, Lille, France.
François BrémontDepartment of Pediatric Pulmonology, University Hospital, Toulouse, France.
Michael J FayonDepartment of Pediatric Pulmonology, University Hospital, CIC 1401, Bordeaux, France.
Christophe DelacourtDepartment of Pediatric Pulmonology, University Hospital Necker-Enfants Malades, APHP, Paris, France; Paris Descartes University, Paris, France.
Caroline LigierINSERM, U 1181, Paris, France; Institut Pasteur, PhEMI, Paris, France; Versailles -Saint -Quentin University, University of Medicine Paris Île-de-France Ouest, EA 4499, Versailles, France.
Laurence WatierINSERM, U 1181, Paris, France; Institut Pasteur, PhEMI, Paris, France; Versailles -Saint -Quentin University, University of Medicine Paris Île-de-France Ouest, EA 4499, Versailles, France.
Didier GuillemotINSERM, U 1181, Paris, France; Institut Pasteur, PhEMI, Paris, France; Versailles -Saint -Quentin University, University of Medicine Paris Île-de-France Ouest, EA 4499, Versailles, France; Department of Epidemiology, APHP, Raymond-Poincaré Hospital, Garches, France.
Children, Antibiotics, Nonsteroidal Anti-inflammatory Drugs and Childhood Empyema (ChANCE) Study Group
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRDélégation Paris 5 · FRInstitut Necker Enfants Malades · FRHôpital Jeanne de Flandre · FRHôpital Necker-Enfants Malades · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the risk factors of empyema after acute viral infection and to clarify the hypothesized association(s) between empyema and some viruses and/or the use of nonsteroidal anti-inflammatory drugs (NSAIDs). STUDY

designA case-control study was conducted in 15 centers. Cases and controls were enrolled for a source population of children 3-15 years of age with acute viral infections between 2006 and 2009.

resultsAmong 215 empyemas, 83 cases (children with empyema and acute viral infection within the 15 preceding days) were included, and 83 controls (children with acute viral infection) were matched to cases. Considering the intake of any drug within 72 hours after acute viral infection onset and at least 6 consecutive days of antibiotic use and at least 1 day of NSAIDs exposure, the multivariable analysis retained an increased risk of empyema associated with NSAIDs exposure (aOR 2.79, 95% CI 1.4-5.58, P = .004), and a decreased risk associated with antibiotic use (aOR 0.32, 95% CI 0.11-0.97, P = .04). The risk of empyema associated with NSAIDs exposure was greater for children not prescribed an antibiotic and antibiotic intake diminished that risk for children given NSAIDs.

conclusionsNSAIDs use during acute viral infection is associated with an increased risk of empyema in children, and antibiotics are associated with a decreased risk. The presence of antibiotic-NSAIDs interaction with this risk is suggested. These findings suggest that NSAIDs should not be recommended as a first-line antipyretic treatment during acute viral infections in children.

Indexed as

Acute DiseaseAdolescentAnti-Bacterial AgentsAnti-Inflammatory Agents, Non-SteroidalCase-Control StudiesChildChild, PreschoolDrug Therapy, CombinationEmpyema, PleuralFemaleHumansInfantLogistic ModelsMaleMultivariate AnalysisRisk FactorsAnti-Bacterial AgentsAnti-Inflammatory Agents, Non-SteroidalchildrenempyemaNSAIDs

Identifiers

PMID27339249
PMCPMC7094675
OpenAlexW2468116420

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.