Evidence map›Paper›PMID 27339192›Full record

ReviewGenome biology2016

Chloroplast genomes: diversity, evolution, and applications in genetic engineering.

Henry Daniell, Choun-Sea Lin, Ming Yu, Wan-Jung Chang

Open access · goldAbstract readReview
In one paragraph

Review in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 994 papers.

0numbers the graph read from it
0cells of the map it votes in
994citing papers in PubMed
44.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

994 citing papers in PubMed, 1,738 citations in OpenAlex.

  1. Article
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  3. The Complete Chloroplast Genome ofEcology and evolution · 2026
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934 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Henry DaniellDepartment of Biochemistry, School of Dental Medicine, University of Pennsylvania, South 40th St, Philadelphia, PA, 19104-6030, USA. hdaniell@upenn.edu.
Choun-Sea LinAgricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.
Ming YuDepartment of Biochemistry, School of Dental Medicine, University of Pennsylvania, South 40th St, Philadelphia, PA, 19104-6030, USA.
Wan-Jung ChangAgricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.
Agricultural Biotechnology Research Center, Academia Sinica · TWUniversity of Pennsylvania · US

Funding

Oral immune modulatory therapy using antigens bioencapsulated in plant cellsR01HL107904 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DANIELL, HENRY · 2011 to 2023
$7.5M
Oral Therapy for Hemophilia AR01HL109442 · NHLBI · UNIVERSITY OF FLORIDA · PI DANIELL, HENRY, HERZOG, ROLAND W. · 2011 to 2015
$3.5M
Expression of Human Therapeutic Proteins in Transgenic Tobacco ChloroplastsR01GM063879 · NIGMS · UNIVERSITY OF CENTRAL FLORIDA · PI DANIELL, HENRY · 2002 to 2010
$2.0M
Oral therapy for diabetic retinopathy using ACE2/Ang1-7 bioencapsulated in plant cellsR01EY024564 · NEI · UNIVERSITY OF FLORIDA · PI DANIELL, HENRY, LI, QIUHONG · 2015 to 2018
$1.6M
NEI NIH HHS R01 EY024564NHLBI NIH HHS R01 HL107904NHLBI NIH HHS R01 HL109442NIGMS NIH HHS R01 GM063879
6 · The paper itself

Abstract

Chloroplasts play a crucial role in sustaining life on earth. The availability of over 800 sequenced chloroplast genomes from a variety of land plants has enhanced our understanding of chloroplast biology, intracellular gene transfer, conservation, diversity, and the genetic basis by which chloroplast transgenes can be engineered to enhance plant agronomic traits or to produce high-value agricultural or biomedical products. In this review, we discuss the impact of chloroplast genome sequences on understanding the origins of economically important cultivated species and changes that have taken place during domestication. We also discuss the potential biotechnological applications of chloroplast genomes.

Indexed as

Evolution, MolecularGenetic VariationChloroplastsGenetic EngineeringGenome, ChloroplastGenome, PlantPhylogenyPlantsTransgenes

Identifiers

PMID27339192
PMCPMC4918201
OpenAlexW2475158195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.