Evidence map›Paper›PMID 27339147›Full record

ArticleInfection2016

Rapid molecular diagnosis of infective aortic valve endocarditis caused by Coxiella burnetii.

Oliver Kumpf, Pascal Dohmen, Martin Ertmer, Fabian Knebel, Alexandra Wiessner, Judith Kikhney, Annette Moter, Sascha Treskatsch

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. LVAD specific infection with Coxiella burnetii treated with heart transplantation and antibiotic suppression.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. State of the Art for Diagnosis of Bacterial Vaginosis.Journal of clinical microbiology · 2023
    Review
  3. Review
  4. Q Fever: A troubling disease and a challenging diagnosis.Clinical microbiology newsletter · 2021
    Article
  5. Article
  6. FluorescenceJournal of clinical microbiology · 2018
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Oliver KumpfDepartment of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany. oliver.kumpf@charite.de.
Pascal DohmenDepartment of Cardiovascular Surgery, Campus Charité Mitte, Charité-University Medicine Berlin, Berlin, Germany.
Martin ErtmerDepartment of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Fabian KnebelDepartment of Cardiology and Angiology, Campus Charité Mitte, Charité-University Medicine Berlin, Berlin, Germany.
Alexandra WiessnerBiofilmcenter, German Heart Institute Berlin, Berlin, Germany.
Judith KikhneyBiofilmcenter, German Heart Institute Berlin, Berlin, Germany.
Annette MoterBiofilmcenter, German Heart Institute Berlin, Berlin, Germany.
Sascha TreskatschDepartment of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEBerlin Heart (Germany) · DEGerman Centre for Cardiovascular Research · DEUniversity of the Free State · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a case of Q-fever endocarditis with severe destruction of the aortic valve with perivalvular abscess formation and cardiac failure. The patient needed urgent operative treatment and postoperative critical care. All specimens sent for microbiological examination were negative. Molecular analysis, including fluorescence in situ hybridization of aortic valve tissue combined with PCR and sequencing, led to the correct diagnosis and to appropriate anti-infective treatment. The patient subsequently recovered from complex cardiovascular surgery. This is the first report on Q-fever endocarditis that was rapidly diagnosed using these methods.

Indexed as

Aortic ValveCoxiella burnetiiEndocarditis, BacterialHeart Valve DiseasesQ FeverHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedMolecular Diagnostic TechniquesChronic infectionCoxiella burnetiiCulture negativeEndocarditisFluorescence in situ hybridizationQ-feverSerology

Identifiers

PMID27339147
OpenAlexW2474063427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.