Evidence map›Paper›PMID 27339086›Full record

ArticleCell research2016

Restoring stem cells - all you need is NAD(.).

Lindsay E Wu, David A Sinclair

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Effects of SRWFood & nutrition research · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Small Molecule Regulators Targeting NADCurrent medicinal chemistry · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics.International journal of tryptophan research : IJTR · 2017
    Review
  12. Meat Intake and the Dose of Vitamin BInternational journal of tryptophan research : IJTR · 2017
    Review
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Lindsay E WuSchool of Medical Sciences, UNSW Australia, Sydney 2052, Australia.
David A SinclairSchool of Medical Sciences, UNSW Australia, Sydney 2052, Australia.
UNSW Sydney · AU

Funding

SIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1M
Elucidating mechanisms of SIRT1 activationR01DK100263 · NIDDK · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2016 to 2020
$2.5M
6 · The paper itself

Abstract

The loss of stem cells, through cell dysfunction or senescence, is thought to contribute to biological aging. Recently, Hongbo Zhang and colleagues have shown that activation of the mitochondrial unfolded protein response, a retrograde stress response, through administration with an NAD-raising compound, can rejuvenate stem cells and extend lifespan in mice.

Indexed as

LongevityNADAnimalsMiceMitochondriaStem CellsUnfolded Protein ResponseNAD

Identifiers

PMID27339086
PMCPMC5034109
OpenAlexW2468492854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.