ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2017
Slowly eroding lesions in multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Patterning Chronic Active Demyelination in Slowly Expanding/Evolving White Matter MS Lesions.AJNR. American journal of neuroradiology · 2020Trial
- Slowly Expanding Lesions in Multiple Sclerosis: A Systematic Review and Meta-Analysis.NeuroSci · 2026Review
- An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis.Annals of clinical and translational neurology · 2025Article
- New Imaging Markers in Multiple Sclerosis and Related Disorders: Smoldering Inflammation and the Central Vein Sign.Neuroimaging clinics of North America · 2024Review
- Lesion-level correspondence and longitudinal properties of paramagnetic rim and slowly expanding lesions in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Potentially toxic elements in the brains of people with multiple sclerosis.Scientific reports · 2023Article
- Recent advances in the longitudinal segmentation of multiple sclerosis lesions on magnetic resonance imaging: a review.Neuroradiology · 2022Review
- Multiple sclerosis: Immunopathological heterogeneity and its implications.European journal of immunology · 2022Review
- Smoldering lesions in MS: if you like it then you should put a rim on it.Neuroradiology · 2022Article
- In vivo imaging of chronic active lesions in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Review
- Predictive MRI Biomarkers in MS-A Critical Review.Medicina (Kaunas, Lithuania) · 2022Review
- Gray matter blood-brain barrier water exchange dynamics are reduced in progressive multiple sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
- Utility of shape evolution and displacement in the classification of chronic multiple sclerosis lesions.Scientific reports · 2020Article
- Profiles of cortical inflammation in multiple sclerosis byMultiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions.Multiple sclerosis (Houndmills, Basingstoke, England) · 2019Article
- Prognostic value of white matter lesion shrinking in early multiple sclerosis: An intuitive or naïve notion?Brain and behavior · 2019Observational
- Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo.JAMA neurology · 2019Article
- A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis.Brain : a journal of neurology · 2019Article
- Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines.Brain : a journal of neurology · 2019Review
- Advances in brain imaging in multiple sclerosis.Therapeutic advances in neurological disorders · 2019Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAt autopsy, 20%-40% of chronic multiple sclerosis (MS) lesions are labeled "slowly expanding" and feature myelin phagocytosis at the lesion edge. As pathological lesion classification relies on a single, terminal time point, the rate of lesion expansion cannot be directly measured.
objectiveTo study long-term volume changes in individual MS lesions.
methodsVolumes of individual lesions on proton density magnetic resonance imaging (MRI) acquired between 1992 and 2015 were measured in 22 individuals (one lesion per person). After correction for acquisition protocol, a mixed model evaluated lesion volume changes.
resultsThe mean (standard deviation) lesion volume at baseline was 142 (82) mL, falling to 74 (51) mL after 16 (3) years. All lesions shrank over time. Change in lesion volume did not correlate with change in supratentorial brain volume ( p = 0.33). In simulations, the results could be explained by a process of slow radial expansion superimposed on substantially more rapid resorption of damaged tissue.
conclusionWe noted sustained radiological contraction of MS lesions, a surprising result given that fresh myelin breakdown products within chronic active lesions are observed relatively frequently at autopsy. Therefore, the primary pathological process in chronic lesions, even those described as "slowly expanding," is likely to be tissue loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.