ArticleScientific reports2016
Evolution of 2009 H1N1 influenza viruses during the pandemic correlates with increased viral pathogenicity and transmissibility in the ferret model.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Infection with Seasonal H1N1 Influenza Results in Comparable Disease Kinetics and Host Immune Responses in Ferrets and Golden Syrian Hamsters.Pathogens (Basel, Switzerland) · 2023Article
- A clinico-epidemiological profile, coinfections and outcome of patients with Influenza Like Illnesses (ILI) presenting to the emergency department during the COVID-19 pandemic.Journal of family medicine and primary care · 2023Article
- The immune system of the ferret (Veterinarni medicina · 2022Review
- Article
- An evolution-based high-fidelity method of epistasis measurement: Theory and application to influenza.PLoS pathogens · 2021Article
- Article
- Beyond the new normal: Assessing the feasibility of vaccine-based suppression of SARS-CoV-2.PloS one · 2021Article
- Structures and functions linked to genome-wide adaptation of human influenza A viruses.Scientific reports · 2019Article
- Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs.Emerging microbes & infections · 2019Article
- ComparativeJournal of virology · 2018Article
- Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies.EBioMedicine · 2018Article
- Sweep Dynamics (SD) plots: Computational identification of selective sweeps to monitor the adaptation of influenza A viruses.Scientific reports · 2018Article
- Pathogenic analysis of the pandemic 2009 H1N1 influenza A viruses in ferrets.The Journal of veterinary medical science · 2017Article
- Generation of Monoclonal Antibodies against Immunoglobulin Proteins of the Domestic Ferret (Journal of immunology research · 2017Article
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Authors and funding
14 authors.
Funding
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Abstract
There is increasing evidence that 2009 pandemic H1N1 influenza viruses have evolved after pandemic onset giving rise to severe epidemics in subsequent waves. However, it still remains unclear which viral determinants might have contributed to disease severity after pandemic initiation. Here, we show that distinct mutations in the 2009 pandemic H1N1 virus genome have occurred with increased frequency after pandemic declaration. Among those, a mutation in the viral hemagglutinin was identified that increases 2009 pandemic H1N1 virus binding to human-like α2,6-linked sialic acids. Moreover, these mutations conferred increased viral replication in the respiratory tract and elevated respiratory droplet transmission between ferrets. Thus, our data show that 2009 H1N1 influenza viruses have evolved after pandemic onset giving rise to novel virus variants that enhance viral replicative fitness and respiratory droplet transmission in a mammalian animal model. These findings might help to improve surveillance efforts to assess the pandemic risk by emerging influenza viruses.
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