Evidence map›Paper›PMID 27338934›Full record

ReviewReviews in endocrine & metabolic disorders2016

Neuroendocrinology of the skin.

Theoharis C Theoharides, Julia M Stewart, Alexandra Taracanova, Pio Conti, Christos C Zouboulis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Review
  4. Keratinocytes: pleiotropic orchestrators of cutaneous immunity and Inflammation - Emerging therapeutic paradigms in dermatological pathologies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  5. Article
  6. Review
  7. The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Probing the Skin-Brain Axis: New Vistas Using Mouse Models.International journal of molecular sciences · 2022
    Review
  12. Review
  13. Review
  14. Psychological Stress, Mast Cells, and Psoriasis-Is There Any Relationship?International journal of molecular sciences · 2021
    Review
  15. Adult skin acute stress responses to short-term environmental and internal aggression from exposome factors.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021
    Review
  16. Article
  17. Article
  18. Skin and Psychosomatics - Psychodermatology today.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2020
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Theoharis C TheoharidesDepartment of Integrative Physiology and Pathobiology, Molecular Immunopharmacology and Drug Discovery Laboratory, Tufts University School of Medicine, 136 Harrison Avenue, Suite J304, Boston, MA, 02111, USA. theoharis.theoharides@tufts.edu.
Julia M StewartDepartment of Integrative Physiology and Pathobiology, Molecular Immunopharmacology and Drug Discovery Laboratory, Tufts University School of Medicine, 136 Harrison Avenue, Suite J304, Boston, MA, 02111, USA.
Alexandra TaracanovaDepartment of Integrative Physiology and Pathobiology, Molecular Immunopharmacology and Drug Discovery Laboratory, Tufts University School of Medicine, 136 Harrison Avenue, Suite J304, Boston, MA, 02111, USA.
Pio ContiDepartment of Graduate Medical Sciences, University of Chieti, Chieti, Italy.
Christos C ZouboulisDepartments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany.
Tufts University · USStädtisches Klinikum Dessau · DEUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a local "hypothalamic-pituitary-adrenal axis." In particular, the peptides corticotropin-releasing hormone (CRH) and neurotensin (NT) have synergistic action stimulating mast cells and are uniquely elevated in the serum of patients with skin diseases exacerbated by stress. Addressing the neurohormonal regulation of skin function could lead to new targets for effective treatment of inflammatory skin diseases.

Indexed as

Corticotropin-Releasing HormoneHumansHypothalamo-Hypophyseal SystemNeurotensinPituitary-Adrenal SystemSkin DiseasesStress, PsychologicalCorticotropin-Releasing HormoneNeurotensinCorticotropin-releasing hormoneHypothalamic-pituitary-adrenal axisNeuroendocrinologyNeurotensinSkin

Identifiers

PMID27338934
OpenAlexW2469615869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.