Trial reportSocial psychiatry and psychiatric epidemiology2016
Adherence to antipsychotic medication among homeless adults in Vancouver, Canada: a 15-year retrospective cohort study.
Trial report in Social psychiatry and psychiatric epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of approaches to improve medication adherence in homeless adults with psychiatric disorders.Frontiers in psychiatry · 2023Pooled it
- Sublingual Buprenorphine-Naloxone Compared With Injection Naltrexone for Opioid Use Disorder: Potential Utility of Patient Characteristics in Guiding Choice of Treatment.The American journal of psychiatry · 2021Trial
- Homeless women with schizophrenia reported lower adherence to their medication than men: results from the French Housing First experience.Social psychiatry and psychiatric epidemiology · 2017Trial
- Housing First Improves Adherence to Antipsychotic Medication Among Formerly Homeless Adults With Schizophrenia: Results of a Randomized Controlled Trial.Schizophrenia bulletin · 2017Trial
- Perspectives of clinicians caring for people experiencing homelessness on point of care tests: an online survey.BMJ open · 2026Article
- Understanding the medication safety challenges for patients with mental illness in primary care: a scoping review.BMC psychiatry · 2023Article
- A Rapid Review of "Low-Threshold" Psychiatric Medication Prescribing: Considerations for Street Medicine and Beyond.Psychiatric services (Washington, D.C.) · 2023Review
- Assessing Outcomes Between Risperidone Microspheres and Paliperidone Palmitate Long-Acting Injectable Antipsychotics Among Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2021Article
- Multivariable modelling of factors associated with criminal convictions among people experiencing homelessness and serious mental illness: a multi-year study.Scientific reports · 2021Article
- Sociodemographic Determinants of Nonadherence to Depression and Anxiety Medication among Individuals Experiencing Homelessness.International journal of environmental research and public health · 2021Article
- Severe Psychopathology and Substance Use Disorder Modify the Association Between Housing Trajectories and Food Security Among Homeless Adults.Frontiers in nutrition · 2021Article
- Recovery-Oriented Outcomes Associated with Long-Acting Injectable Antipsychotics in an Urban Safety-Net Population.Community mental health journal · 2019Observational
- Characteristics of adherence to methadone maintenance treatment over a 15-year period among homeless adults experiencing mental illness.Addictive behaviors reports · 2017Article
- Adherence to Antipsychotic Medication and Criminal Recidivism in a Canadian Provincial Offender Population.Schizophrenia bulletin · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeThe purpose of this study was to investigate the level of adherence to antipsychotic prescription medication in a well-defined homeless cohort over a 15-year period. We hypothesized that adherence would be well below the recommended threshold for clinical effectiveness (80 %), and that it would be strongly associated with modifiable risk factors in the social environment in which homeless people live.
methodLinked baseline data (including comprehensive population-level administrative prescription records) were examined in a subpopulation of participants from two pragmatic-randomized trials that investigated Housing First for homeless and mentally ill adults. Adherence to antipsychotic medication was operationalized using the medication possession ratio. Multivariable logistic regression was used to estimate effect sizes between socio-demographic, homelessness-related and illness factors, and medication possession ratio.
resultsAmong the 290 participants who met inclusion criteria for the current analysis, adherence to antipsychotic prescription was significantly associated with: history of psychiatric hospitalization; receipt of primary medical services; long-acting injectable antipsychotic formulations; and duration of homelessness. Mean medication possession ratio in the pre-randomization period was 0.41. Socio-demographic characteristics previously correlated with antipsychotic non-adherence were not significantly related to medication possession ratio.
conclusionsThis is the first study to quantify the very low level of adherence to antipsychotic medication among homeless people over an extended observation period of 15 years. Each of the four factors found to be significantly associated with adherence presents opportunities for intervention. Strategies to end homelessness for this population may represent the greatest opportunity to improve adherence to antipsychotic medication.
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