ArticleEpidemiology and infection2016
Whole genome sequencing improved case ascertainment in an outbreak of Shiga toxin-producing Escherichia coli O157 associated with raw drinking milk.
Article in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Assessment of the Microbiological Quality of Raw Milk Sold Through Vending Machines at the Farm Level in Switzerland.Pathogens (Basel, Switzerland) · 2026Article
- Mind the gap! TypingMicrobial genomics · 2026Article
- An outbreak of Shiga toxin-producingEpidemiology and infection · 2025Article
- Article
- Animal and environmental risk factors for sporadic Shiga toxin-producing Escherichia coli (STEC) infection in England: a case control study for O157, O26 and other STEC serotypes.Pathogens and global health · 2023Article
- Transforming Shiga toxin-producingFrontiers in microbiology · 2023Article
- Outbreak of STEC O157:H7 linked to a milk pasteurisation failure at a dairy farm in England, 2019.Epidemiology and infection · 2022Article
- Evidence of on-going transmission of Shiga toxin-producingEpidemiology and infection · 2021Article
- A cluster of Shiga Toxin-producingEpidemiology and infection · 2021Article
- Antibiotic Resistance: One Health One World Outlook.Frontiers in cellular and infection microbiology · 2021Review
- Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020Review
- The Benefits of Whole Genome Sequencing for Foodborne Outbreak Investigation from the Perspective of a National Reference Laboratory in a Smaller Country.Foods (Basel, Switzerland) · 2020Article
- Assessing the genomic relatedness and evolutionary rates of persistent verotoxigenicMicrobial genomics · 2020Article
- Microbiological quality of raw drinking milk and unpasteurised dairy products: results from England 2013-2019.Epidemiology and infection · 2020Article
- Campylobacter outbreak associated with raw drinking milk, North West England, 2016.Epidemiology and infection · 2020Article
- Gastrointestinal infections caused by consumption of raw drinking milk in England & Wales, 1992-2017.Epidemiology and infection · 2019Article
- Status and potential of bacterial genomics for public health practice: a scoping review.Implementation science : IS · 2019Article
- Emergence and divergence of major lineages of Shiga-toxin-producing Escherichia coli in Australia.Microbial genomics · 2019Article
- Outbreak of Shiga toxin-producingEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Impact of whole genome sequencing on the investigation of food-borne outbreaks of Shiga toxin-producingEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Five cases of STEC O157 phage type (PT) 21/28 reported consumption of raw cows' drinking milk (RDM) produced at a dairy farm in the South West of England. STEC O157 PT21/28 was isolated from faecal specimens from milking cows on the implicated farm. Whole genome sequencing (WGS) showed that human and cattle isolates were the same strain. Further analysis of WGS data confirmed that sequences of isolates from an additional four cases (who did not report consumption of RDM when first questioned) fell within the same five single nucleotide polymorphism cluster as the initial five cases epidemiologically linked to the consumption of RDM. These four additional cases identified by WGS were investigated further and were, ultimately, associated with the implicated farm. The RDM outbreak strain encoded stx2a, which is associated with increased pathogenicity and severity of symptoms. Further epidemiological analysis showed that 70% of isolates within a wider cluster containing the outbreak strain were from cases residing in, or linked to, the same geographical region of England. During this RDM outbreak, use of WGS improved case ascertainment and provided insights into the evolution of a highly pathogenic clade of STEC O157 PT21/28 stx2a associated with the South West of England.
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