Evidence map›Paper›PMID 27338456›Full record

ArticleNutrients2016

Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial.

Caihong Sun, Mingyang Zou, Dong Zhao, Wei Xia, Lijie Wu

Open access · goldAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 70 citations in OpenAlex.

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  17. Diet in treatment of autism spectrum disorders.Frontiers in neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Caihong SunDepartment of Children's and Adolescent Health, Public Health College of Harbin Medical University, Harbin 150081, China. suncaihong2003@163.com.
Mingyang ZouDepartment of Children's and Adolescent Health, Public Health College of Harbin Medical University, Harbin 150081, China. mingyangshine@sina.com.
Dong ZhaoZhejiang Provincial Center For Disease Prevention and Control, Hangzhou 310009, China. dzhao@cdc.zj.cn.
Wei XiaDepartment of Children's and Adolescent Health, Public Health College of Harbin Medical University, Harbin 150081, China. xiawei1023@126.com.
Lijie WuDepartment of Children's and Adolescent Health, Public Health College of Harbin Medical University, Harbin 150081, China. wulijiehyd@126.com.
Harbin Medical University · CNZhejiang Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorders (ASD) are recognized as a major public health issue. Here, we evaluated the effects of folic acid intervention on methylation cycles and oxidative stress in autistic children enrolled in structured teaching. Sixty-six autistic children enrolled in this open-label trial and participated in three months of structured teaching. Forty-four children were treated with 400 μg folic acid (two times/daily) for a period of three months during their structured teaching (intervention group), while the remaining 22 children were not given any supplement for the duration of the study (control group). The Autism Treatment Evaluation Checklist (ATEC) and Psychoeducational Profile-third edition (PEP-3) were measured at the beginning and end of the treatment period. Folic acid, homocysteine, and glutathione metabolism in plasma were measured before and after treatment in 29 autistic children randomly selected from the intervention group and were compared with 29 age-matched unaffected children (typical developmental group). The results illustrated folic acid intervention improved autism symptoms towards sociability, cognitive verbal/preverbal, receptive language, and affective expression and communication. Furthermore, this treatment also improved the concentrations of folic acid, homocysteine, and normalized glutathione redox metabolism. Folic acid supplementation may have a certain role in the treatment of children with autism.

Indexed as

Dietary SupplementsAutistic DisorderCase-Control StudiesChildChild, PreschoolFemaleFolic AcidHumansMaleTeachingFolic Acidautismfolic acid interventionglutathione redox statushomocysteinestructured teaching

Identifiers

PMID27338456
PMCPMC4924178
OpenAlexW2413945315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.