Evidence map›Paper›PMID 27338339›Full record

ReviewMolecules (Basel, Switzerland)2016

Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders.

Birgit Waltenberger, Andrei Mocan, Karel Šmejkal, Elke H Heiss, Atanas G Atanasov

Full text readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Therapeutic potential of phytochemical compounds in cardiovascular disease: a comprehensive review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Molecules (Basel, Switzerland) · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Journal of pharmaceutical analysis · 2024
    Article
  13. Article
  14. Review
  15. Heliyon · 2024
    Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Birgit Waltenberger *Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria; birgit.waltenberger@uibk.ac.at.
Andrei Mocan *Department of Pharmaceutical Botany, Iuliu Haţieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania; mocan.andrei@umfcluj.ro.
Karel ŠmejkalDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic; karel.mejkal@post.cz.
Elke H HeissDepartment of Pharmacognosy, University of Vienna, 1090 Vienna, Austria; elke.heiss@univie.ac.at.
Atanas G AtanasovDepartment of Pharmacognosy, University of Vienna, 1090 Vienna, Austria; elke.heiss@univie.ac.at.

Funding

Austrian Science Fund FWF P 25971
6 · The paper itself

Abstract

Natural products have always been exploited to promote health and served as a valuable source for the discovery of new drugs. In this review, the great potential of natural compounds and medicinal plants for the treatment or prevention of cardiovascular and metabolic disorders, global health problems with rising prevalence, is addressed. Special emphasis is laid on natural products for which efficacy and safety have already been proven and which are in clinical trials, as well as on plants used in traditional medicine. Potential benefits from certain dietary habits and dietary constituents, as well as common molecular targets of natural products, are also briefly discussed. A glimpse at the history of statins and biguanides, two prominent representatives of natural products (or their derivatives) in the fight against metabolic disease, is also included. The present review aims to serve as an "opening" of this special issue of Molecules, presenting key historical developments, recent advances, and future perspectives outlining the potential of natural products for prevention or therapy of cardiovascular and metabolic disease.

Indexed as

Plants, MedicinalBiguanidesBiological ProductsCardiovascular DiseasesDrug DiscoveryHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMetabolic DiseasesBiguanidesBiological ProductsHydroxymethylglutaryl-CoA Reductase Inhibitorsbiguanidescardiovascular diseasecoffeediabetes mellitusdietary constituentsmetabolic disordersmolecular targetsnatural productsstatins

Identifiers

PMID27338339
PMCPMC4928700

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.