ArticleMolecules (Basel, Switzerland)2016
Optimization of Preparation Conditions for Lysozyme Nanoliposomes Using Response Surface Methodology and Evaluation of Their Stability.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Nanoliposomes for the Delivery of Food Bioactive Compounds: Preparation, Characterization, and Application in Precision Nutrition.Chemistry & biodiversity · 2026Review
- Development and Characterization of Spray-Dried Curcumin-Lecithin Complexes with Improved Solubility and In Vitro Digestive and Thermal Stability.Foods (Basel, Switzerland) · 2025Article
- Encapsulation of Green Tea Extract (GTE) in Nanoliposome and Assessment of Its Characterization and In Vitro Release Study of GTE.Food science & nutrition · 2025Article
- Study of the Stability and Anti-Inflammatory Activity of Paeonol-Oleanolic Acid Liposomes by Microfluidic Technology.Foods (Basel, Switzerland) · 2025Article
- Optimization of Instant Beverage Powder Containing Propolis Extract Nanoliposomes.International journal of food science · 2024Article
- Preparation and Optimization of Ibrutinib-Loaded Nanoliposomes Using Response Surface Methodology.Polymers · 2022Article
- Preparation of Drug-Loaded Liposomes with Multi-Inlet Vortex Mixers.Pharmaceutics · 2022Article
- Lipid-Based Nanostructures for the Delivery of Natural Antimicrobials.Molecules (Basel, Switzerland) · 2021Review
- Article
- New formulation of vitamin C encapsulation by nanoliposomes: production and evaluation of particle size, stability and control release.Food science and biotechnology · 2019Article
- Optimization of Conditions for Cyanidin-3-OGlucoside (C3G) Nanoliposome Production by Response Surface Methodology and Cellular Uptake Studies in Caco-2 Cells.Molecules (Basel, Switzerland) · 2017Article
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Authors and funding
6 authors.
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Abstract
The main purpose of this study was to optimize the preparation of lysozyme nanoliposomes using response surface methodology and measure their stability. The stabilities of lysozyme nanoliposomes in simulated gastrointestinal fluid (SGF), simulated intestinal fluid (SIF), as well as pH, temperature and sonication treatment time were evaluated. Reverse-phase evaporation method is an easy, speedy, and beneficial approach for nanoliposomes' preparation and optimization. The optimal preparative conditions were as follows: phosphatidylcholine-to-cholesterol ratio of 3.86, lysozyme concentration of 1.96 mg/mL, magnetic stirring time of 40.61 min, and ultrasound time of 14.15 min. At the optimal point, encapsulation efficiency and particle size were found to be 75.36% ± 3.20% and 245.6 nm ± 5.2 nm, respectively. The lysozyme nanoliposomes demonstrated certain stability in SGF and SIF at a temperature of 37 °C for 4 h, and short sonication handling times were required to attain nano-scaled liposomes. Under conditions of high temperature, acidity and alkalinity, lysozyme nanoliposomes are unstable.
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