Evidence map›Paper›PMID 27338314›Full record

ArticleMolecules (Basel, Switzerland)2016

Antimicrobial Activity and Modulatory Effect of Essential Oil from the Leaf of Rhaphiodon echinus (Nees & Mart) Schauer on Some Antimicrobial Drugs.

Antonia Eliene Duarte, Irwin Rose Alencar de Menezes, Maria Flaviana Bezerra Morais Braga, Nadghia Figueiredo Leite, Luiz Marivando Barros, Emily Pansera Waczuk, Maria Arlene Pessoa da Silva, Aline Boligon, João Batista Teixeira Rocha, Diogo Onofre Souza and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

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  10. High Potency ofMolecules (Basel, Switzerland) · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Antonia Eliene DuarteCentro de Ciências Biológicas e da Saúde (CC BS), Departamento de Ciências Biológicas, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil. duarte105@yahoo.com.br.
Irwin Rose Alencar de MenezesMolecular Chemistry and Pharmacology Laboratory, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil. irwin.alencar@urca.br.
Maria Flaviana Bezerra Morais BragaCentro de Ciências Biológicas e da Saúde (CC BS), Departamento de Ciências Biológicas, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil. flavianamoraisb@yahoo.com.br.
Nadghia Figueiredo LeiteCentro de Ciências Biológicas e da Saúde (CC BS), Departamento de Ciências Biológicas, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil. nadghia.fl@gmail.com.
Luiz Marivando BarrosCentro de Ciências Biológicas e da Saúde (CC BS), Departamento de Ciências Biológicas, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil. lmarivando@hotmail.com.
Emily Pansera WaczukPrograma de Pós-Graduação em Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil. memypw@yahoo.com.br.
Maria Arlene Pessoa da SilvaCentro de Ciências Biológicas e da Saúde (CC BS), Departamento de Ciências Biológicas, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil. arlene.pessoa@urca.br.
Aline BoligonPrograma de Pós-Graduação em Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil. alineboligon@hotmail.com.
João Batista Teixeira RochaPrograma de Pós-Graduação em Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil. jbtrocha@yahoo.com.br.
Diogo Onofre SouzaDepartamento de Bioquímica, Instituto de Ciências Básica da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-191, RS, Brazil. diogo@ufrgs.br.
Jean Paul KamdemPrograma de Pós-Graduação em Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil. kamdemjeanpaul2005@yahoo.fr.
Henrique Douglas Melo CoutinhoLaboratory of Microbiology and Molecular Biology, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil. hdmcoutinho@gmail.com.
Marilise Escobar BurgerPrograma de Pós-Graduação em Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil. mariliseeb@yahoo.com.br.
Universidade Federal de Santa Maria · BRUniversidade Regional do Cariri · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRhaphiodon echinus is a weed plant used in the Brazilian folk medicinal for the treatment of infectious diseases. In this study, the essential oil of R. echinus leaf was investigated for its antimicrobial properties.

methodsThe chemical constituents of the essential oil were characterized by GC-MS. The antimicrobial properties were determined by studying by the microdilution method the effect of the oil alone, and in combination with antifungal or antibiotic drugs against the fungi Candida albicans, Candida krusei and Candida tropicalis and the microbes Escherichia coli, Staphylococcus aureus and Pseudomonas. In addition, the iron (II) chelation potential of the oil was determined.

resultsThe results showed the presence of β-caryophyllene and bicyclogermacrene in major compounds, and revealed a low antifungal and antibacterial activity of the essential oil, but a strong modulatory effect on antimicrobial drugs when associated with the oil. The essential oil showed iron (II) chelation activity.

conclusionsThe GC-MS characterization revealed the presence of monoterpenes and sesquiterpenes in the essential oil and metal chelation potential, which may be responsible in part for the modulatory effect of the oil. These findings suggest that essential oil of R. echinus is a natural product capable of enhancing the antibacterial and antifungal activity of antimicrobial drugs.

Indexed as

Antifungal AgentsAnti-Infective AgentsBrazilCandida albicansEscherichia coliHumansInfectionsLamiaceaeMonoterpenesOils, VolatilePlant LeavesPlant OilsSesquiterpenesStaphylococcus aureusAntifungal AgentsAnti-Infective AgentsMonoterpenesOils, VolatilePlant OilsSesquiterpenesantibacterial activityantifungal activitymodulatingnatural productsR. echinus

Identifiers

PMID27338314
PMCPMC6274211
OpenAlexW2413162998

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.