Evidence map›Paper›PMID 27338010›Full record

ArticleScientific reports2016

The association between polyomavirus BK strains and BKV viruria in liver transplant recipients.

Robert Y L Wang, Yi-Jung Li, Wei-Chen Lee, Hsin-Hsu Wu, Chan-Yu Lin, Cheng-Chia Lee, Yung-Chang Chen, Cheng-Chieh Hung, Chih-Wei Yang, Ya-Chung Tian

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Pathogenicity of BK virus on the urinary system.Central European journal of urology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Robert Y L WangDepartment of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yi-Jung LiKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Wei-Chen LeeDepartment of General Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan.
Hsin-Hsu WuKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chan-Yu LinKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Cheng-Chia LeeKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Yung-Chang ChenKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Cheng-Chieh HungKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chih-Wei YangKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Ya-Chung TianKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chang Gung Memorial Hospital · TWChang Gung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to understand the prevalence of BKV infection and identified of BKV various strains in the urine of liver transplant recipients. There was not significant difference of renal outcome between high BKV viruria and low BKV viruria in the liver transplant recipients. The WW-non-coding control region (NCCR) BKV detected in urine was associated with higher urinary BKV load, whereas the Dunlop-NCCR BKV was detected in the urine of low urinary BKV load. An in vitro cultivation system demonstrated that WW-BKV strain exhibiting the higher viral DNA replication efficiency and higher BKV load. Altogether, this is the first study to demonstrate the impact of BKV strains on the occurrence of BK viruria in the liver transplant recipients.

Indexed as

BK VirusDNA, ViralFemaleHumansKidneyKidney TransplantationLiverLiver TransplantationMaleMiddle AgedPolyomavirusPolyomavirus InfectionsPrevalenceRisk FactorsTransplantation, HomologousTumor Virus InfectionsDNA, Viral

Identifiers

PMID27338010
PMCPMC4919687
OpenAlexW2468031304

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.