Evidence map›Paper›PMID 27337983›Full record

ArticleScientific reports2016

A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics.

Antoine Chaillon, Martin Hoenigl, Sanjay R Mehta, Nadir Weibel, Susan J Little, Davey M Smith

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Web-based models to inform health policy: A scoping review.Health research policy and systems · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Antoine ChaillonDivision of Infectious Diseases, University of California, San Diego, La Jolla, California, United States of America.
Martin HoeniglDivision of Infectious Diseases, University of California, San Diego, La Jolla, California, United States of America.
Sanjay R MehtaDivision of Infectious Diseases, University of California, San Diego, La Jolla, California, United States of America.
Nadir WeibelDepartment of Computer Science and Engineering, University of California San Diego, California, United States.
Susan J LittleDivision of Infectious Diseases, University of California, San Diego, La Jolla, California, United States of America.
Davey M SmithDivision of Infectious Diseases, University of California, San Diego, La Jolla, California, United States of America.

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Translational Methamphetamine AIDS Research Center (TMARC)P50DA026306 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 2009 to 2018
$33.9M
Transmission ProbabilityP01AI074621 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2008 to 2012
$23.1M
Primary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1M
Southern California Primary Infection ProgramU01AI043638 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RICHMAN, DOUGLAS D · 1998 to 2010
$21.3M
Molecular Epidemiology for HIV Prevention for Drug Users and Other Risk Groups DP1DA034978 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2016
$4.1M
Efficacy of ART to Interrupt HIV Transmission NetworksR01MH100974 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2014 to 2018
$3.2M
Mentoring Translational Research in HIVK24AI100665 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2021
$1.5M
Molecular Epidemiology of HIV-1 in the California-Mexico Border RegionK23AI093163 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEHTA, SANJAY R · 2011 to 2015
$643k
Characterizing Privacy Perceptions and Risks in HIV Molecular EpidemiologyR21AI108351 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KALICHMAN, MICHAEL W, LITTLE, SUSAN JANET · 2014 to 2015
$426k
NIAID NIH HHS K23 AI093163NIAID NIH HHS K24 AI100665NIAID NIH HHS P01 AI074621NIAID NIH HHS P30 AI036214NIAID NIH HHS R21 AI108351NIAID NIH HHS R24 AI106039NIAID NIH HHS U01 AI043638NIDA NIH HHS DP1 DA034978NIDA NIH HHS P50 DA026306NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH100974
6 · The paper itself

Abstract

It remains unclear what proportions of HIV-infected and uninfected people should receive effective antiretroviral therapy (ART) to control local HIV epidemics. We developed a flexible model to evaluate the impact of treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP) on HIV incidence in local communities. We evaluated this tool for determining what TasP and PrEP targets are needed to substantially reduce the HIV epidemic in San Diego, which is predominately comprised of men who have sex with men. By increasing the proportion of HIV-infected individuals on ART from 30% to 50%, 686 new infections would be prevented over five years in San Diego. By providing PrEP to 30% of MSM to the age group that account for 90% of local HIV incident cases (21-52 years), we could prevent 433 infections over five years. When combining these initiatives, a PrEP coverage rate of 40% and TasP coverage rate of 34% would be expected to decrease the number of new infections by over half in one year. This online tool is designed to help local public health planners and policy makers to estimate program outcomes and costs that may lead to better control of their local HIV epidemics.

Indexed as

EpidemicsModels, BiologicalAdultAge FactorsAnti-Retroviral AgentsCaliforniaDisease SusceptibilityHealth PolicyHIV InfectionsHomosexuality, MaleHumansIncidenceInternetMaleMiddle AgedPre-Exposure ProphylaxisAnti-Retroviral Agents

Identifiers

PMID27337983
PMCPMC4919622

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.